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OBJECTIVE We examined trends in incidence of treatment for diabetes-related end-stage renal disease (ESRD) in the U.S. RESEARCH DESIGN AND METHODS Using the U.S. Renal Data System, we obtained the number of individuals having diabetes listed as primary diagnosis who initiated ESRD treatment between 1990 and 2006. Incidence was calculated using the(More)
OBJECTIVE To investigate the effects of modafinil, a new central stimulant, on visual and auditory motion reaction ability and subjective fatigue level during 48 h sleep deprivation (SD). METHOD Six male healthy young volunteers were exposed to two 48 h periods of continuous wakefulness during the crossover experiment. In one period, three 200 mg doses of(More)
p38 mitogen-activated protein kinase (MAPK) is an essential kinase involved in myogenic differentiation. Although many substrates of p38 MAPK have been identified, little is known about its upstream activators during myogenic differentiation. TRAF6 is known to function in cytokine signaling during inflammatory responses. However, not much is known about its(More)
This paper conducts a Bayesian analysis of inverse Gaussian process models for degradation modeling and inference. Novel features of the Bayesian analysis are the natural manners for incorporating subjective information, pooling of random effects information among product population, and a straightforward way of coping with evolving data sets for on-line(More)
OBJECTIVE To assess trends in rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in U.S. diabetic and nondiabetic populations and disparities in NLEA rates within the diabetic population. RESEARCH DESIGN AND METHODS We calculated NLEA hospitalization rates, by diabetes status, among persons aged ≥40 years on the basis of National(More)
The rapidly increasing pace and continuously evolving reliability requirements of new products have made life cycle reliability assessment of new products an imperative yet difficult work. While much work has been done to separately estimate reliability of new products in specific stages, a gap exists in carrying out life cycle reliability assessment(More)
—The redundancy allocation problem has been extensively studied with the aim of determining optimal redundancy levels of components at various stages to achieve the required system reliability or availability. In most existing studies, failed elements are assumed to be as good as new after repair, from a failure perspective. Due to deterioration, the(More)
Hepatocyte transplantation has the potential to cure inherited liver diseases, but its application is impeded by a scarcity of donor livers. Therefore, we explored whether transplantation of hepatocyte-like cells (iHeps) differentiated from human induced pluripotent stem cells (iPSCs) could ameliorate inherited liver diseases. iPSCs reprogrammed from human(More)