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Transport of preproteins into the mitochondrial matrix is mediated by the presequence translocase-associated motor (PAM). Three essential subunits of the motor are known: mitochondrial Hsp70 (mtHsp70); the peripheral membrane protein Tim44; and the nucleotide exchange factor Mge1. We have identified the fourth essential subunit of the PAM, an essential(More)
OBJECTIVE We examined trends in incidence of treatment for diabetes-related end-stage renal disease (ESRD) in the U.S. RESEARCH DESIGN AND METHODS Using the U.S. Renal Data System, we obtained the number of individuals having diabetes listed as primary diagnosis who initiated ESRD treatment between 1990 and 2006. Incidence was calculated using the(More)
This paper conducts a Bayesian analysis of inverse Gaussian process models for degradation modeling and inference. Novel features of the Bayesian analysis are the natural manners for incorporating subjective information, pooling of random effects information among product population, and a straightforward way of coping with evolving data sets for on-line(More)
OBJECTIVE To assess trends in rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in U.S. diabetic and nondiabetic populations and disparities in NLEA rates within the diabetic population. RESEARCH DESIGN AND METHODS We calculated NLEA hospitalization rates, by diabetes status, among persons aged ≥40 years on the basis of National(More)
OBJECTIVE Patients with diabetes are at an increased risk for developing corneal complications and delayed wound healing. This study investigated the effects of high glucose on epidermal growth factor receptor (EGFR) signaling and on epithelial wound healing in the cornea. RESEARCH DESIGN AND METHODS Effects of high glucose on wound healing and on EGFR(More)
—The redundancy allocation problem has been extensively studied with the aim of determining optimal redundancy levels of components at various stages to achieve the required system reliability or availability. In most existing studies, failed elements are assumed to be as good as new after repair, from a failure perspective. Due to deterioration, the(More)
The rapidly increasing pace and continuously evolving reliability requirements of new products have made life cycle reliability assessment of new products an imperative yet difficult work. While much work has been done to separately estimate reliability of new products in specific stages, a gap exists in carrying out life cycle reliability assessment(More)
Different speech detection sensors have been developed over the years but they are limited by the loss of high frequency speech energy, and have restricted non-contact detection due to the lack of penetrability. This paper proposes a novel millimeter microwave radar sensor to detect speech signals. The utilization of a high operating frequency and a(More)