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Kindlin-3 Mediates Integrin αLβ2 Outside-in Signaling, and It Interacts with Scaffold Protein Receptor for Activated-C Kinase 1 (RACK1)*
- C. Feng, Yanfeng Li, +9 authors Suet-Mien Tan
- Biology, Medicine
- The Journal of Biological Chemistry
- 10 February 2012
Background: Kindlin-3 is a cytoplasmic protein that binds and modulates the ligand binding property of integrin αLβ2. Results: Kindlin-3 induces integrin αLβ2 clustering, and it interacts with the… Expand
Sandwich-type Au-PEI/DNA/PEI-Dexa nanocomplex for nucleus-targeted gene delivery in vitro and in vivo.
- Zhen-zhen Chen, Lifen Zhang, Yuling He, Yanfeng Li
- Materials Science, Medicine
- ACS applied materials & interfaces
- 24 July 2014
Many synthetic Au-based cationic nanoparticles (AuNPs) for nonviral gene delivery show high efficiency in vitro, but their excessive charge density, harsh reducing conditions, and nontarget delivery… Expand
FSCB phosphorylation in mouse spermatozoa capacitation.
It is generally accepted that spermatozoa capacitation is associated with protein kinase A-mediated tyrosine phosphorylation. In our previous study, we identified the fibrous sheath CABYR binding… Expand
The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2.
- Yanfeng Li, Renhong Tang, Kia-Joo Puan, S. Law, Suet-Mien Tan
- The Journal of biological chemistry
The integrin alphaLbeta2 mediates leukocyte adhesion and migration that are required for a functional immune system. It is known that inside-out signaling triggers alphaLbeta2 conformational changes,… Expand
Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece.
The leukocyte-restricted integrin alpha(L)beta(2) is required in immune processes such as leukocyte adhesion, migration, and immune synapse formation. Activation of alpha(L)beta(2) by conformational… Expand
HIPK4 is essential for murine spermiogenesis
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are… Expand
Roles of Te and Mn in the two phases of manganite with nominal composition La0.6Sr0.1TexMnO3
Powder samples with nominal composition La0.6Sr0.1TexMnO3 (x = 0.00, 0.05, 0.10, 0.15, 0.20) were prepared using the sol-gel method with thermal treatment up to 1473 K. On the basis of powder X-ray… Expand
Study of the free energy of the La1−xCaxMnO3 manganites based on the temperature dependence of the crystal cell volume
A study of the free energy of the perovskite manganites was performed by fitting experimental results for the temperature dependence of the crystal cell volume using a detailed semiclassical model of… Expand