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Production of salidroside in metabolically engineered Escherichia coli
TLDR
This work achieved unprecedented biosynthesis of salidroside (1) from glucose in a microorganism by introducing Rhodiola-derived glycosyltransferase UGT73B6 into the above-mentioned recombinant strain and catalyzing the attachment of glucose to the phenol position of tyrosol to form icariside D2, which was not reported in any previous literatures.
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De novo biosynthesis of Gastrodin in Escherichia coli.
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Synthetic Life with Alternative Nucleic Acids as Genetic Materials
TLDR
This review outlines some recent studies in which the storage and propagation of genetic information are achieved in vivo by expanding genetic systems with XNAs.
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CRISPR‐based curing and analysis of metabolic burden of cryptic plasmids in Escherichia coli Nissle 1917
TLDR
It is found that curing of cryptic plasmids may not be necessary for optimal heterologous expression in this host, and replacement of pMUT2 with an engineered version containing an inserted antibiotic resistance reporter gene and demonstrated that the engineered plasmid was stable over 90 generations without selection.
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Biosynthesis of phlorisovalerophenone and 4-hydroxy-6-isobutyl-2-pyrone in Escherichia coli from glucose
TLDR
The report of biosynthesis of phlorisovalerophenone and 4-hydroxy-6-isobutyl-2-pyrone in E. coli adds a new example to the list of valuable compounds synthesized in E- coli from renewable carbon resources by type III PKSs.
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Production and Sensing of Butyrate in a Probiotic E. coli Strain
TLDR
This work has engineered a model probiotic organism, E. coli Nissle 1917, to produce butyrate from genomic loci up to approximately 1 g/L (11 mM), and developed a high-throughput biosensor that responds to intracellularbutyrate concentrations, with green fluorescent protein as the reporter.
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Engineered short branched-chain acyl-CoA synthesis in E. coli and acylation of chloramphenicol to branched-chain derivatives
TLDR
To the authors' knowledge, this is the first report of production of short branched-chain acyl-CoAs in E. coli and opens a way to biosynthesize various valuable natural compounds based on these special building blocks from renewable carbon sources.
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Fermentative Production of Phenolic Glucosides by Escherichia coli with an Engineered Glucosyltransferase from Rhodiola sachalinensis.
TLDR
This study demonstrated the substrate flexibility of the glucosyltransferase mutant UGT73B6FS toward aromatic alcohols but also provided an effective and economical method to produce phenolic glucosides by fermentation circumventing the use of expensive precursor UDP-glucose.
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Impact of Combined Acidic and Hyperosmotic Shock Conditions on the Proteome ofListeria monocytogenesATCC 19115 in a Time-Course Study
TLDR
Proteome profiling provided a better understanding of the physiological responses of this pathogen to adapt to lethal nonthermal environments and indicates the need to improve food processing and storage methods, especially for non- or minimally thermally processed foods.
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Construction of synthetic life forms with genetic materials comprising unnatural nucleic acids
TLDR
Chemical synthetic biologists gain more insight into the chemical etiology of ribofuranosyl nucleic acids DNA/ RNA, and the chemical basis for genetic functions including information storage, heredity and evolution.
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