Yanfei shen Dongming Zhang

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In diabetic patients complicated with colorectal cancer (CRC), metformin treatment was reported to have diverse correlation with CRC-specific mortality. In laboratory studies, metformin was reported to affect the survival of cancer stem cells (CSCs) in breast and pancreatic cancers and glioblastoma. Although cscs play a critical role in the resistance to(More)
The H.264/JVT video coding standard can achieve considerably higher coding eflcieney than prcvious standards. Unforfunafely this comes at the cost of greatly increased complexi@ at the encoder mainly due to multi-reference frames and multi-block type motion estimation. In order to speed up the process of multi-block type motion estimation, in this paper a(More)
A stable component model is the precondition of a successful implementation of component-based system. High-quality components identification technology is considered as the basis of modeling business components. This paper proposes a new method of business component identification by using graph segmentation; the identification method focuses on three(More)
OBJECTIVES The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, as one of the key genes involved in the folate pathway, has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs). However, the results of published studies are contradictory and inconclusive. Thus, this meta-analysis aimed to evaluate the effect of the(More)
An algorithm using compressive sensing to blindly detect frequency hopping signals corrupted by white Gaussian noise is presented. The samples obtained through compressive sensing effectively maintain structures and information of the original signal, so detection tasks of the original signal could be solved by directly processing the sampling values. The(More)
BACKGROUND The overexpression of key enzymes in a metabolic pathway is a frequently used genetic engineering strategy for strain improvement. Metabolic control analysis has been proposed to quantitatively determine key enzymes. However, the lack of quality data often makes it difficult to correctly identify key enzymes through control analysis. Here, we(More)
Bipolar disorder (BD) is a psychiatric disease characterized by alternating episodes of mania and depression. Lithium (Li) represents the mainstay treatment for BD, although a significant proportion of patients shows insufficient or no response. Li is also associated with potentially severe side effects, including renal effects. Several studies reported(More)
Subchondral bone plays a key role in the development of osteoarthritis, however, epigenetics of subchondral bone has not been extensively studied. In this study, we examined the genome-wide DNA methylation profiles of subchondral bone from three regions on tibial plateau representing disease progression using HumanMethylation450 BeadChip to identify(More)
Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10). We investigated the effects of IFN-α on the(More)
Previous research indicates that microRNA-25 (miR-25) regulates carcinogenesis and the progression of various cancers, but the role of miR-25 in melanoma remains unclear. We observed that miR-25 was significantly upregulated in melanoma cell lines and tissue samples. Downregulation of miR-25 markedly suppressed invasion and proliferation of melanoma cells(More)