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1039Background: Previous studies have indicated that the mechanism of HER2 activation include not only HER2 protein overexpression and gene amplification but also HER2 somatic mutations. The impact… Continue Reading
Oncogenic fusions are rare in colorectal carcinomas, but may be important for prognosis and therapy. An effective strategy for screening targetable oncogenic fusions in colorectal carcinomas is… Continue Reading
High-level tissue tumor mutational burden (tTMB) or blood TMB (bTMB) are associated with better response of immunotherapy in non-small cell lung cancer (NSCLC) patients. However, the correlations of… Continue Reading
ABSTRACT In this study, we report here a rare case of polycythemia and cRCC in the same patient, which may be helpful in understanding clinical features and molecular mechanisms underlying… Continue Reading
3569Background: Neoadjuvant chemoradiotherapy (nCRT) is nowadays the standard of care for the locally advanced rectal cancer (LARC). However, there is no effective method to predict patients’ possi...
6056Background: In this study, tumor derived Cell-free DNA (cfDNA) is detected in plasma and saliva samples in head and neck squamous carcinomas (HNSCC), as well as genomic variants in para-carcino...
Through next generation sequencing, this study evaluated the circulating tumor DNA (ctDNA) of advanced breast cancer patients to prospectively explore the relationship between specific DNA mutations… Continue Reading
e16053Background: Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors with high mortality. Radiation therapy (RT) is currently one of the main treatments to ESCC. Circulat...
Context Von Hippel–Lindau (VHL) disease manifests as a variety of benign and malignant neoplasms. Previous studies of VHL disease have documented several genotype–phenotype correlations; however,… Continue Reading