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N-Acylated homoserine lactone (AHL) lactonases are capable of degrading signal molecules involved in bacterial quorum sensing and therefore represent a new approach to control bacterial infection. Here a gene responsible for the AHL lactonase activity of Bacillus sp. strain AI96, 753 bp in length, was cloned and then expressed in Escherichia coli. The(More)
BACKGROUND Aeromonas hydrophila is a serious pathogen and can cause hemorrhagic septicemia in fish. To control this disease, antibiotics and chemicals are widely used which can consequently result in "superbugs" and chemical accumulation in the food chain. Though vaccine against A. hydrophila is available, its use is limited due to multiple serotypes of(More)
Sina Weibo, the most popular microblogging service in China, plays a significance role in sharing and exchanging information on local and global level. Actually, part of the information are correlated with some events which may be local ones such as accident, protests or natural disasters to widely ones such as events concerning well-known people or(More)
With the rapid growth of event-based social networks (EBSNs) like Meetup, the demand for event recommendation becomes increasingly urgent. In EBSNs, event recommendation plays a central role in recommending the most relevant events to users who are likely to participate in. Different from traditional recommendation problems, event recommendation encounters(More)
Cache reliability is increasingly a concern as cache cell dimension shrinks and cache capacity grows. Conventionally, an extra, dedicated storage is appended to cache to store error correcting code. Recently, cache compression schemes have been proposed to increase the effective cache capacity of last-level cache (LLC), for which we found the conventional(More)
Functional pancreatic neuroendocrine tumours (PNETs) are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycaemia. The major genetic alterations in sporadic insulinomas are still unknown. Here we identify recurrent somatic T372R mutations in YY1 by whole exome sequencing of 10 sporadic insulinomas. Further(More)
Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic beta cells. We have found that menin contains two functional nuclear export signals and that there is nuclear accumulation of beta-catenin in Men1-null(More)
Adrenal Cushing's syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders. We performed whole-exome sequencing of 49 blood-tumor pairs and RNA sequencing of 44 tumors from cortisol-producing adrenocortical adenomas (ACAs), adrenocorticotropic hormone-independent macronodular(More)
The α-galactosidase gene, galA17, was cloned from Flavobacterium sp. TN17, a symbiotic bacterium isolated from the gut of Batocera horsfieldi larvae. The 2,205-bp full-length gene encodes a 734-residue polypeptide (GalA17) containing a putative 28-residue signal peptide and a catalytic domain belonging to glycosyl hydrolase family 36 (GH 36). The deduced(More)
PURPOSE Hyperglycemia-induced endothelial damage is a key pathogenetic factor in diabetic retinopathy. Endothelial damage may lead to phenotypic changes in the cells manifested by reduced expression of endothelial markers and increased expression of mesenchymal markers, termed endothelial to mesenchymal transition (EndMT). We investigated mechanisms of such(More)