Yana A Zabrodskaya

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A mirror-symmetry motif was discovered in the N-terminus of the influenza virus PB1 protein. Structure of peptide comprised of the corresponding part of PB1 (amino acid residues 6-25) was investigated by circular dichroism and in silico modeling. We found that peptide PB1 (6-25) in solution assumes beta-hairpin conformation. A truncated peptide PB1 (6-13),(More)
In this study, we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by(More)
33 Today, biological objects are studied using various microscopy methods: electronic microscopy (EM), confocal microscopy (CM), and atomic force micros copy (AFM). One of the advantages of AFM is the ability to study biological objects in solution at a reso lution comparable to that of electron microscopy. In EM and CM, there are methods based on the use(More)
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