Yan-qing Zhang

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AIM To evaluate the peroxynitrite (ONOO(-)) of puerarin on retinal pigment epithelial (RPE) cells apoptosis induced partly by peroxynitrite via Fas/FasL. METHODS RPE cells from C57BL/6 mice eyes were cultured. Diabetes was induced in Sprague-Dawley (SD) rats by streptozotocin (STZ) intraperitoneal injection. Puerarin was administrated to cultured RPE(More)
Alzheimer's disease (AD) is a common progressive neurodegenerative disorder associated with cholinergic neurons degeneration. The blood-brain barrier (BBB) not only provides protection for the brain but also hinders the treatment and diagnosis of this neurological disease, because the drugs must cross BBB to reach the lesions. The present work was aimed at(More)
The aim of the study was mainly to investigate the relationship between concentration of rivastigmine and its inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) following intranasal (IN) and intravenous (IV) administration in rats, and to provide a novel nasal delivery route for the brain disease therapy. Rivastigmine was(More)
OBJECTIVE The therapeutic effects of general and local applications of puerarin in the treatment of streptozotocin (STZ)-induced rat diabetic model were compared. METHODS Experimental research. We equally divided normal Sprague-Dawley (SD) rats into a STZ group, a peritoneal injection group, a peribulbar injection group and a control group. STZ,(More)
BACKGROUND Retinal pigment epithelial (RPE) cell is a monolayer of multifunctional cells between the retina and the choroid. Peroxynitrite (ONOO(-)) is known to induce toxicity on RPE cells. This study aimed to evaluate ONOO(-) induced expression of inducible nitric oxide synthase (iNOS) and complement 3 (C3) via Fas/FasL pathway in RPE cells and the values(More)
OBJECTIVE To explore whether skin fibroblasts could be used as a cell source for reconstruction of the corneal stroma. METHODS It was an experimental study. Skin fibroblast cells were isolated from newborn rabbits, cultured and expanded in vitro. Cells were labeled with green fluorescence protein (GFP) gene by retro-viral infection. Fibroblasts at passage(More)
AIM To investigate the treatment status and prognosis of space-occupying lacrimal gland lesions at one tertiary eye center in China. METHODS A retrospective clinical study was performed on 95 patients with space-occupying lesions of the lacrimal gland surgically treated at the Eye & ENT Hospital of Fudan University from 2003 to 2007. The reviewed clinical(More)
OBJECTIVE To investigate the application of Rose and Wright's algorithm in diagnosing lacrimal gland masses. DESIGN Retrospective observational cases series. PARTICIPANTS A total of 93 consecutive patients with primary masses within the orbital lobe of the lacrimal gland were reviewed. METHODS Before treatment, patients' detailed history was collected(More)
AIM To evaluate the toxicity of endogeneous peroxynitrite on transplanted retinal pigment epithelial (RPE) sheets and the effect of puerarin on their survival in the C57BL/6 mice after RPE sheets have been transplanted into SD rats' subretinal space . METHODS C57BL/6 mice eyes were used to culture RPE cells. Ninety-six SD rats were involved in the(More)
OBJECTIVE To study the change of tear film and lacrimal secretion after lacrimal gland tumor removal operation. METHODS It was a retrospective case series study. Nineteen cases (19 eyes) with pleomorphic adenoma of the lacrimal gland from January, 2010 to July, 2011 in Eye and ENT Hospital of Fudan University were elected. The evaluation included(More)
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