Yan-ping Chen

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The apoptosis-stimulating protein of p53 (ASPP) family comprises three members, namely, ASPP1, ASPP2, and iASPP. They regulate the promotive effect of p53 on apoptosis. Breast cancer (BC) remains as one of the leading causes of cancer or cancer-related mortality among women. However, the relationship between the ASPP family members and p53, as well as the(More)
OBJECTIVE To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were(More)
Merkel cell carcinoma (MCC) is a relatively rare but aggressive primary neuroendocrine carcinoma of the skin. MCC frequently occurs on sun-exposed areas in elderly Caucasian patients and has a propensity for local recurrence, regional lymph node invasion and distant metastases. However, MCC occurring on sites that are not sun-exposed in Asian patients is(More)
Langerhans cell sarcoma (LCS) is a rare tumor with markedly malignant cytological features originating from Langerhans cells. LCS diagnosis is difficult and requires differentiation from other malignant tumors and Langerhans cell histiocytosis (LCH). Immunochemical antibodies, such as langerin, S-100 protein, and CD1a, have been used to diagnose LCS, but(More)
Background. Cyanoacrylate injection (GVO) and band ligation (GVL) are effective treatments for gastric variceal hemorrhage. However, data on the optimal treatment are still controversial. Methods. For our overall analysis, relevant studies were identified from several databases. For each outcome, data were pooled using a fixed-effect or random-effects model(More)
BACKGROUND Remifentanil, an ultra-short-acting opioid, is widely used for pain control during surgery. However, regular dose (RD) remifentanil exacerbates postoperative pain in a dose-dependent manner. Recent studies suggest that high-dose (HD) remifentanil offers sustained analgesia in experimental studies. We thus hypothesized that intraoperative(More)
Maladaptive neuropathic pain results from injury or disease of the nervous system. It is typically chronic and frequently intractable. Standard analgesics, such as opioids, are of little use, while gabapentinoids (pregabalin and gabapentin) are not universally effective. In peripherally generated neuropathic pain, an initial inflammatory response releases a(More)
OBJECTIVE To explore the inhibitory effect of spinal topical morphine on the dorsal horn projection neurons in nerve-injured rats and its mechanism. METHODS Single-unit activity of dorsal horn projection neurons was recorded in anesthetized L(5)/L(6) nerve-ligated rats. Allodynia was determined by a behavior test in nerve-injured rats. The evoked neuronal(More)
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