Yan-li Hao

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OBJECTIVE To understand the function of Sonic hedgehog in chiasm development in mouse embryos of embryonic day 13 (E13) to E15. METHODS Brain slices of E13-E15 mouse embryos containing the optic pathway from the eyes to the optic tract were prepared and cultured in DMEM/F12 in the presence of 10% fetal bovine serum at 37 degrees in a rolling incubator for(More)
OBJECTIVE To explore the difference between adolescent and adult C57BL/6J mice in response to rapid eye movement sleep (REMS) deprivation in terms of anxiety behavior and hippocampal NO level. METHODS Both adolescent and adult C57BL/6J mice were divided into normal control (NC) group, wide platform (WP) group, and 24-hour REMS deprivation group, each(More)
OBJECTIVE To examine the change of Smoothened (Smo) expression in the retinofugal pathway and in the growth cones during the period of embryonic day 13 (E13) to E15. METHODS Smo expression in the chiasm and growth cones was observed by fluorescent immunostaining and retinal explant culture. RESULTS On E13 and E14, Smo was expressed moderately in the(More)
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