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The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how confinement and adhesion affect this(More)
In this paper, a direct adaptive neural network control algorithm based on the backstepping technique is proposed for a class of uncertain nonlinear discrete-time systems in the strict-feedback form. The neural networks are utilized to approximate unknown functions, and a stable adaptive neural network controller is synthesized. The fact that all the(More)
In this paper, an adaptive control algorithm is proposed for a class of robot manipulator systems with unknown functions and dead-zone input by using a reinforcement learning scheme. The parameters of the dead zone are supposed to be unknown but bounded. The unknown functions can be approximated based on the neural networks, which is one part of the(More)
In this article, a direct adaptive neural networks control algorithm is presented for a class of SISO discrete-time systems with non-symmetric dead-zone. The property of the dead-zone is discretized. Mean value theorem is used to transform the systems into a special form. The unknown functions in the input–output model are approximated using the radial(More)
Human pluripotent stem cells including human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are cells displaying abilities of unlimited self-renewal and differentiation into any somatic cell type. These unique properties make them increasingly attractive for novel applications in disease modeling, drug discovery, and cell therapy(More)
In the present study, we demonstrate that prolonged treatment by trastuzumab induced resistance of NCI-N87 gastric cancer cells to trastuzumab. The resistant cells possessed typical characteristics of epithelial to mesenchymal transition (EMT)/cancer stem cells and acquired more invasive and metastatic potentials both in vitro and in vivo. Long term(More)
BACKGROUND Recent studies have demonstrated that microRNA-22 (miR-22) was deregulated in many types of cancers and was involved in various cellular processes related to carcinogenesis. However, the clinical significance and prognostic value of miR-22 in epithelial ovarian cancer (EOC) haven't been investigated. METHODS 109 pairs of fresh EOC tissue and(More)
In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a nonadhesive surface(More)
In this paper, the stability and control issues of a class of uncertain nonlinear discrete-time systems in the strict feedback form are investigated. The dead-zone input in the systems, whose property is non-symmetric and discretized, is investigated. The unknown functions in the systems are approximated by using the radial basis function neural networks(More)
The use of chemotherapy to treat cancer is effective, but chemoresistance reduces this efficacy. Chemotherapy resistance involves several mechanisms, including the cancer stem cell (CSC) concept. The aim of the present study was to assess whether paclitaxel-resistant epithelial ovarian carcinoma is capable of generating cells with CSC-like properties. Using(More)