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The three-dimensional crystal structure of the Escherichia coli methionine repressor, MetJ, complexed with a DNA operator fragment is described in an accompanying article. The complex exhibits several novel features of DNA-protein interaction. DNA sequence recognition is achieved largely by hydrogen-bond contacts between the bases and amino-acid side chains(More)
The p38 mitogen-activated protein kinase (MAPK) identified in human monocytes represents a potentially attractive therapeutic target for a class of cytokine suppressive anti-inflammatory compounds. However, the limitations of protein therapeutics have stimulated significant research aimed at developing orally bioavailable, small molecular inhibitors of(More)
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