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The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage and whole-body energy homeostasis. However, the mechanisms regulating the formation, expansion, and interconversion of these 2 distinct types of fat remain unknown. Recently, the lysosomal degradative pathway of macroautophagy has been identified(More)
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies have analyzed Treg frequency in the peripheral blood mononuclear cells (PBMCs) of pancreatic ductal adenocarcinoma (PDA) patients using flow cytometry (FCM), few studies have examined how intratumoral Tregs might contribute to immunosuppression in the tumor(More)
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces "white adipocytes" with characteristics of brown fat and leads to a reduction of adiposity and its metabolic complications. Although BMP4 is known to induce commitment of pluripotent stem cells to the adipocyte lineage by producing cells that possess the(More)
The harmful effects of the environmental carcinogen, benzo[a]pyrene (B[a]P), on mammalian neurodevelopment and behavior as yet remain unclear. Several studies have suggested that B[a]P impairs learning and memory. In the present investigation, we investigated the effects of subchronic exposure to B[a]P on rats. Male rats received daily injection of B[a]P(More)
A 1-Tb/s single-channel coherent optical OFDM (CO-OFDM) signal consisting of continuous 4,104 spectrally-overlapped subcarriers is generated using a novel device of recirculating frequency shifter (RFS). The RFS produces 320.6-GHz wide spectrum using a single laser with superior flatness and tone-to-noise ratio (TNR). The 1-Tb/s CO-OFDM signal is comprised(More)
Antisocial personality disorder (ASPD) is closely connected to criminal behavior. A better understanding of functional connectivity in the brains of ASPD patients will help to explain abnormal behavioral syndromes and to perform objective diagnoses of ASPD. In this study we designed an exploratory data-driven classifier based on machine learning to(More)
OBJECTIVE To investigate the effects of oral dydrogesterone for luteal phase support after frozen embryo transfer (FET) cycles on the clinical outcomes. METHODS A total of 1643 FET cycles in our center between January, 2010 and September, 2011 were analyzed. The patients were divided into group A with natural-cycle FET and group B with hormone replacement(More)
Clostridium beijerinckii mutant strain IB4, which has a high level of inhibitor tolerance, was screened by low-energy ion implantation and used for butanol fermentation from a non-detoxified hemicellulosic hydrolysate of corn fiber treated with dilute sulfuric acid (SAHHC). Evaluation of toxicity showed C. beijerinckii IB4 had a higher level of tolerance(More)
Checkpointing and replaying is an attractive technique that has been used widely at the operating/runtime system level to provide fault tolerance. Applying such a technique at the application level can benefit a range of software engineering tasks such as testing of long-running programs, automated debugging, and dynamic slicing. We propose a(More)
Speech output, whether live, recorded or synthetic, is often employed in difficult listening conditions. Context-sensitive speech modifications aim to promote intelligibility while maintaining quality and listener comfort. The current study used objective measures of intelligibility and quality to compare five energy reallocation strategies operating under(More)