Yan-Ru Lou

Publications32
h-index15
Citations1,116
Highly Influential Citations33
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Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
Recently, the detection of occult cancer cells in peripheral blood has received a great deal of attention regarding the prediction of postoperative cancer recurrence and for novel strategies of… Expand
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Increased anxiety in mice lacking vitamin D receptor gene
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various… Expand
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25‐Hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
According to the present paradigm, 1α,25‐dihydroxyvitamin D3 [1α,25‐(OH)2D3] is a biologically active hormone; whereas 25‐hydroxyvitamin D3 (25OHD3) is regarded as a prohormone activated through the… Expand
  • 97
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Premature aging in vitamin D receptor mutant mice
Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23). Here we… Expand
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Antiproliferative action of vitamin D.
During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration… Expand
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Impaired motor performance in mice lacking neurosteroid vitamin D receptors
Vitamin D is a neuroactive seco-steroid and its importance to the nervous system is receiving increasing recognition. Since numerous data link vitamin D dysfunctions to various neurological and… Expand
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Role of 24‐hydroxylase in vitamin D3 growth response of OVCAR‐3 ovarian cancer cells
Vitamin D and its analogues are potent regulators of cell growth and differentiation both in vivo and in vitro. We studied the effects of 25‐hydroxyvitamin D3 [25(OH)D3], 1,25‐dihydroxyvitamin D3… Expand
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25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand
25-Hydroxyvitamin D(3) 1alpha-hydroxylase encoded by CYP27B1 converts 25-hydroxyvitamin D(3) into 1alpha,25-dihydroxyvitamin D(3), a vitamin D receptor ligand. 25-Hydroxyvitamin D(3) has been… Expand
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Progressive Hearing Loss in Mice with a Mutated Vitamin D Receptor Gene
Background: Both hypo- and hypervitaminosis D can cause sensorineural hearing loss, and aural symptoms due to vitamin D insufficiency are especially common during gravidity. Hormonal forms of vitamin… Expand
  • 62
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Thalamic calcification in vitamin D receptor knockout mice
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice… Expand
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