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- Publications
- Influence
Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
Recently, the detection of occult cancer cells in peripheral blood has received a great deal of attention regarding the prediction of postoperative cancer recurrence and for novel strategies of… Expand
Increased anxiety in mice lacking vitamin D receptor gene
- A. Kalueff, Yan-Ru Lou, I. Laaksi, P. Tuohimaa
- Biology, Medicine
- Neuroreport
- 7 June 2004
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various… Expand
25‐Hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
- Yan-Ru Lou, I. Laaksi, +4 authors P. Tuohimaa
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 February 2004
According to the present paradigm, 1α,25‐dihydroxyvitamin D3 [1α,25‐(OH)2D3] is a biologically active hormone; whereas 25‐hydroxyvitamin D3 (25OHD3) is regarded as a prohormone activated through the… Expand
Premature aging in vitamin D receptor mutant mice
- T. Keisala, A. Minasyan, Yan-Ru Lou, J. Zou, P. Tuohimaa
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 1 July 2009
Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23). Here we… Expand
Antiproliferative action of vitamin D.
- T. Ylikomi, I. Laaksi, +7 authors P. Tuohimaa
- Biology, Medicine
- Vitamins and hormones
- 2002
During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration… Expand
Impaired motor performance in mice lacking neurosteroid vitamin D receptors
- A. Kalueff, Yan-Ru Lou, I. Laaksi, P. Tuohimaa
- Biology, Medicine
- Brain Research Bulletin
- 30 July 2004
Vitamin D is a neuroactive seco-steroid and its importance to the nervous system is receiving increasing recognition. Since numerous data link vitamin D dysfunctions to various neurological and… Expand
Role of 24‐hydroxylase in vitamin D3 growth response of OVCAR‐3 ovarian cancer cells
- S. Miettinen, M. Ahonen, +4 authors T. Ylikomi
- Biology, Medicine
- International journal of cancer
- 20 January 2004
Vitamin D and its analogues are potent regulators of cell growth and differentiation both in vivo and in vitro. We studied the effects of 25‐hydroxyvitamin D3 [25(OH)D3], 1,25‐dihydroxyvitamin D3… Expand
25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand
- Yan-Ru Lou, F. Molnár, M. Peräkylä, S. Qiao, P. Tuohimaa
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 15 February 2010
25-Hydroxyvitamin D(3) 1alpha-hydroxylase encoded by CYP27B1 converts 25-hydroxyvitamin D(3) into 1alpha,25-dihydroxyvitamin D(3), a vitamin D receptor ligand. 25-Hydroxyvitamin D(3) has been… Expand
Progressive Hearing Loss in Mice with a Mutated Vitamin D Receptor Gene
- J. Zou, A. Minasyan, +6 authors P. Tuohimaa
- Biology, Medicine
- Audiology and Neurotology
- 1 June 2008
Background: Both hypo- and hypervitaminosis D can cause sensorineural hearing loss, and aural symptoms due to vitamin D insufficiency are especially common during gravidity. Hormonal forms of vitamin… Expand
Thalamic calcification in vitamin D receptor knockout mice
- A. Kalueff, E. Loseva, +8 authors Pentii Tuchimaa
- Biology, Medicine
- Neuroreport
- 15 May 2006
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice… Expand