Yan Ping Du

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Important advances in rapid magnetic resonance (MR) imaging technology and its application to cardiovascular imaging have been made during the past decade. High-field-strength clinical magnets, high-performance gradient hardware, and ultrafast pulse sequence technology are rapidly making the vision of a comprehensive "one-stop shop" cardiac MR imaging(More)
OBJECTIVES We sought: 1) to investigate the relationship between vascular wall shear stress and flow-mediated dilation (FMD) in humans, and 2) to investigate whether this relationship could explain why FMD is greater in small arteries. BACKGROUND Arterial wall shear stress (WSS) is considered to be the primary stimulus for the endothelial-dependent FMD(More)
Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual response. The development of improved opioid analgesics requires high-throughput functional assays to assess large numbers of potential opioid ligands. In this study, we assessed the ability of a(More)
It was previously found that a phosphorothioated antisense oligodeoxynucleotide (ETASODN) significantly inhibits production of endothelin-1 (ET-1). The purpose of the present study was to determine whether intracerebroventricular injection of ETASODN targeted to prepro-ET-1 is capable of exerting the same preventing effect on the aorta narrowing of(More)
OBJECTIVE To investigate the effects of different drugs on systolic blood pressure (SBP) and left ventricular hypertrophy (LVH) in spontaneously hypertensive rats under cold stress. METHODS A total of 40 male spontaneously hypertensive rats aged 10 weeks (160~200 g) were given adaptive feeding for 7 days at a temperature of 20±1°C and then randomly(More)