Yan Pang

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Selective translation of survival proteins is an important facet of the cellular stress response. We recently demonstrated that this translational control involves a stress-specific reprogramming of modified ribonucleosides in tRNA. Here we report the discovery of a step-wise translational control mechanism responsible for survival following oxidative(More)
A tutorial introduction is provided to the relatively new subject of hybrid systems. The modelling of hybrid systems is assuming ever greater importance for systems where the combination of continuous control and with logical decision making is required. This arises in some of the most critical operating regions where systems are under start-up, shutdown or(More)
A renewed interest in non-coding RNA (ncRNA) has led to the discovery of novel RNA species and post-transcriptional ribonucleoside modifications, and an emerging appreciation for the role of ncRNA in RNA epigenetics. Although much can be learned by amplification-based analysis of ncRNA sequence and quantity, there is a significant need for direct analysis(More)
Mitochondrial single nucleotide polymorphisms (mtSNPs) have been reported to associate with type-2 diabetes mellitus (T2DM), but mtSNPs appear to be considerably different among different populations and regions. To determine mtSNPs in Chinese Han patients with T2DM, the entire sequences of the mitochondrial genomes from 72 T2DM Chinese (59 +/- 4 years) and(More)
The aim of the present study was to determine the clinical value of autologous immunocyte therapy as a standard treatment regimen for patients with cancer. A total of 121 patients with cancer were included in this study. Subsequent to performing leukapheresis using the Fresenius Kabi System, 1x10 7 dendritic cells (DCs) for the vaccine and 1x10 9(More)
A Mobile Ad-Hoc Network (MANET) is a self-configuring infrastructureless network of mobile devices connected by wireless. Most of the existing ad-hoc routing algorithms select the shortest path using various resources. However the selected path may not be the best path for video applications. The problems with existing methods are frequent route change with(More)
Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib has been approved for treatment of advanced ovarian cancer associated with BRCA1 and BRCA2 mutations. BRCA1- and BRCA2-mutated cells, which are homologous recombination (HR) deficient, are hypersensitive to PARPi through the mechanism of synthetic lethality. Here we examine the effect of PARPi(More)
PURPOSE To determine the immune response after dendritic cell (DC) vaccine and cytokine-induced killer cells (CIK) therapy and assess its associated toxicity, survival benefit, and changes in the quality of life (QOL) of advanced colorectal cancer (CRC) patients. METHODS We recruited 100 patients with unresectable CRC orrelapsed CRC after surgery who(More)