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Hashing is a popular approximate nearest neighbor search approach for large-scale image retrieval. Supervised hashing, which incorporates similar-ity/dissimilarity information on entity pairs to improve the quality of hashing function learning, has recently received increasing attention. However, in the existing supervised hashing methods for images, an(More)
Similarity-preserving hashing is a widely-used method for nearest neighbour search in large-scale image retrieval tasks. For most existing hashing methods, an image is first encoded as a vector of hand-engineering visual features, followed by another separate projection or quantization step that generates binary codes. However, such visual feature vectors(More)
Future many-core processors will require high-performance yet energy-efficient on-chip networks to provide a communication substrate for the increasing number of cores. Recent advances in silicon nanophotonics create new opportunities for on-chip networks. To efficiently exploit the benefits of nanophotonics, we propose Firefly - a hybrid, hierarchical(More)
On-chip network is becoming critical to the scalability of future many-core architectures. Recently, nanophotonics has been proposed for on-chip networks because of its low latency and high bandwidth. However, nanophotonics has relatively high static power consumption, which can lead to inefficient architectures. In this work, we propose FlexiShare —(More)
The mechanisms of human mutant superoxide dismutase-1 (mSOD1) toxicity to motor neurons (MNs) are unresolved. We show that MNs in G93A-mSOD1 transgenic mice undergo slow degeneration lacking similarity to apoptosis structurally and biochemically. It is characterized by somal and mitochondrial swelling and formation of DNA single-strand breaks prior to(More)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes paralysis. Some forms of ALS are inherited, caused by mutations in the superoxide dismutase-1 (SOD1) gene. The mechanisms of human mutant SOD1 (mSOD1) toxicity to MNs are unresolved. Mitochondria in MNs might be key sites for ALS pathogenesis, but(More)
—This paper studies a constrained optical signal-to-noise ratio (OSNR) optimization problem in optical networks from the perspective of system performance. A system optimization problem is formulated with the objective of achieving an OSNR target for each channel while satisfying the total power constraint. In order to establish existence of a unique(More)
Alpha-synuclein (alpha-Syn) is enriched in nerve terminals. Two mutations in the alpha-Syn gene (Ala53--> Thr and Ala30--> Pro) occur in autosomal dominant familial Parkinson's disease. Mice overexpressing the human A53T mutant alpha-Syn develop a severe movement disorder, paralysis, and synucleinopathy, but the mechanisms are not understood. We examined(More)
There are many ongoing investigations to improve the oral bioavailability of peptide and protein formulations. Bioadhesive polysaccharide chitosan nanoparticles (CS-NPs) would seem to further enhance intestinal absorption of them. In this study, Insulin-loaded CS-NPs were prepared by ionotropic gelation of CS with tripolyphosphate anions. Its particle size(More)
Multi-view clustering, which seeks a partition of the data in multiple views that often provide complementary information to each other, has received considerable attention in recent years. In real life clustering problems, the data in each view may have considerable noise. However, existing clustering methods blindly combine the information from multi-view(More)