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Future many-core processors will require high-performance yet energy-efficient on-chip networks to provide a communication substrate for the increasing number of cores. Recent advances in silicon nanophotonics create new opportunities for on-chip networks. To efficiently exploit the benefits of nanophotonics, we propose Firefly - a hybrid, hierarchical(More)
Hashing is a popular approximate nearest neighbor search approach for large-scale image retrieval. Supervised hashing, which incorporates similarity/dissimilarity information on entity pairs to improve the quality of hashing function learning, has recently received increasing attention. However, in the existing supervised hashing methods for images, an(More)
Similarity-preserving hashing is a widely-used method for nearest neighbour search in large-scale image retrieval tasks. For most existing hashing methods, an image is first encoded as a vector of hand-engineering visual features, followed by another separate projection or quantization step that generates binary codes. However, such visual feature vectors(More)
On-chip network is becoming critical to the scalability of future many-core architectures. Recently, nanophotonics has been proposed for on-chip networks because of its low latency and high bandwidth. However, nanophotonics has relatively high static power consumption, which can lead to inefficient architectures. In this work, we propose FlexiShare —(More)
Multi-view clustering, which seeks a partition of the data in multiple views that often provide complementary information to each other, has received considerable attention in recent years. In real life clustering problems, the data in each view may have considerable noise. However, existing clustering methods blindly combine the information from multi-view(More)
Alpha-synuclein (alpha-Syn) is enriched in nerve terminals. Two mutations in the alpha-Syn gene (Ala53--> Thr and Ala30--> Pro) occur in autosomal dominant familial Parkinson's disease. Mice overexpressing the human A53T mutant alpha-Syn develop a severe movement disorder, paralysis, and synucleinopathy, but the mechanisms are not understood. We examined(More)
The mechanisms of human mutant superoxide dismutase-1 (mSOD1) toxicity to motor neurons (MNs) are unresolved. We show that MNs in G93A-mSOD1 transgenic mice undergo slow degeneration lacking similarity to apoptosis structurally and biochemically. It is characterized by somal and mitochondrial swelling and formation of DNA single-strand breaks prior to(More)
Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2(More)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes paralysis. Some forms of ALS are inherited, caused by mutations in the superoxide dismutase-1 (SOD1) gene. The mechanisms of human mutant SOD1 (mSOD1) toxicity to MNs are unresolved. Mitochondria in MNs might be key sites for ALS pathogenesis, but(More)
The effects of salinity and drought on the antioxidative system (SOD, POD, CAT) were studied in liquorice seedlings (Glycyrrhiza uralensis Fisch). The results showed that both salt and drought stresses could induce oxidative stress, as indicated by the increase level of lipid peroxidation. The activities of SOD and POD were up-regulated by salt and drought(More)