Yan Liu

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Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate single-stranded oligonucleotides (ssODN) mediated knockin by(More)
Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway. Silencing the SOST gene using RNA interference (RNAi) could therefore be an effective way to treat osteoporosis. Here, we investigate the utility of lipid(More)
In case of software architecture reconstruction, design pattern detection plays a vital role since its presence reflects the point of design decision. Currently most of the studied approaches only focus on the Gang of Four (GOF) design patterns so those tools are not flexible enough to identify other proprietary pattern instances. Moreover, the GOF design(More)
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