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Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation
Improved function recovery was found which was paralleled by a reduction of apoptosis after metformin treatment, which implied met formin to be a potential drug for SCI therapy. Expand
Effects of dietary combinations of organic acids and medium chain fatty acids as a replacement of zinc oxide on growth, digestibility and immunity of weaned pigs
Abstract Two experiments were conducted to evaluate effects of dietary solid mixture of organic acids and medium chain fatty acids (MCFA) as a replacement of zinc oxide (ZnO) on growth, digestibilityExpand
AIP1 Recruits Phosphatase PP2A to ASK1 in Tumor Necrosis Factor–Induced ASK1-JNK Activation
A critical role of PP2A-AIP1 complex in TNF-induced activation of ASK1-JNK apoptotic signaling is supported, as demonstrated by both overexpression and small interfering RNA knockdown approaches. Expand
Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.
It is concluded that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells. Expand
Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction.
Along with its established activities in ECM degradation, CatS plays novel roles in TGF-β1 signalling, myofibroblast trans-differentiation, and ECM protein synthesis, thereby regulating scar formation in the infarcted myocardium and preserving LV function after experimental MI. Expand
Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy
The characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy are discussed. Expand
Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice
It is shown that in replete wild-type mice, Rapa significantly inhibits both homeostatic and alloantigen-induced proliferation of Treg, and promotes their apoptosis, which leads to significant Treg depletion. Expand
Expression and Function of Kisspeptin during Mouse Decidualization
KISS-1 and GPR54 proteins were spatiotemporally expressed in decidualizing stromal cells in intact pregnant females, as well as in pseudopregnant mice undergoing artificially inducedDecidualization. Expand
Nox4 inhibition enhances the cytotoxicity of cisplatin in human renal cancer cells.
Nox4 contributes to RCC chemo-resistance through modulation of pro-APoptotic and anti-apoptotic signaling, suggesting that Nox4 inhibition might enhance the efficacy of conventional cytotoxic drugs against RCC. Expand
Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers
The research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers is explored, including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. Expand