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Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia.
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Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis
TLDR
This investigation adopted a consensus docking/scoring strategy to screen for novel SIRT2 inhibitors and discovered 2-((5-benzyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(naphthalen-1-yl]acetamide (SR86), which could serve as a promising lead compound, hence deserving further studies.
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Emulsified Isoflurane Produces Cardiac Protection After Ischemia-Reperfusion Injury in Rabbits
TLDR
The results indicate that, in rabbits, IV emulsified isoflurane provides similar myocardial protection against ischemia-reperfusion injury as inhaled isofLurane.
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XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models
TLDR
XIST can induce neuropathic pain development in CCI rats via upregulating ZEB1 by acting as a sponge of miR‐150 and the XIST/miR‐ 150/ZEB1 axis can be provided as a therapeutic target in neuropathicPain.
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Inhibition of miR‐200b/miR‐429 contributes to neuropathic pain development through targeting zinc finger E box binding protein‐1
TLDR
The results suggested that miR‐200b/miR‐429 can serve as an important regulator of neuropathic pain development by targeting ZEB1.
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The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats.
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Protective Effect of PNU-120596, a Selective Alpha7 Nicotinic Acetylcholine Receptor–positive Allosteric Modulator, on Myocardial Ischemia–reperfusion Injury in Rats
TLDR
PNU might have a protective effect against MIRI, its action mechanisms might be involved in the inhibition of inflammatory responses, attenuation of lipid peroxidation, and suppression of nuclear factor kappa B activity.
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Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE.
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Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation
TLDR
Findings indicate that honokiol pretreatment diminished myocardial I/R injury through attenuation of oxidative stress and inflammation.
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Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats
TLDR
Compared with CLP group, propofol treatment reversed hypotension, slightly steadied heartbeats, and decreased the plasma TNF-α and IL-6 levels, and significantly suppressed NF-κB activation.
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