Yan-Jun Guo

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We compared clinical data from two related Chinese patients with fatal familial insomnia (FFI) and collected information about their pedigree. The clinical features in the two cases were similar and included initial progressive insomnia and sympathetic activation, which persisted throughout the clinical course. A total of 135 members of this family, across(More)
Dendritic gold (Au) nanoparticles have been successfully synthesized by the one-step hydrothermal reduction of HAuCl4.4H2O using ammonium formate (AF) as a reducing agent in the presence of PVP. Effects of different reactant concentrations on the morphologies of obtained products have been systematically investigated. On the basis of the morphologies of the(More)
Very long chain fatty acids (VLCFAs) play a comprehensive role in organisms. They are essential biological components in seed storage triacylglycerols (TAGs), membrane lipids, and sphingolipids. They also serve as precursors of wax layer compounds. The cuticle covers the aerial surface of land plants, which consists of cutin and wax. The wax, including(More)
OBJECTIVE To investigate the epidemiological, genealogic characteristic, familial history of the families with fatal familial insomnia, its clinical and pathological features as well as the heredity rule of related genes. METHODS 135 familial members of 7 eras were studied. Vein blood samples from patients as well as from some familial members were(More)
Galectin-1 (Gal-1) shows neuroprotective activity in brain ischemia, spinal cord injury, and autoimmune neuroinflammation. To evaluate the Gal-1 situation in the brains of prion disease, the brain levels of Gal-1 in several scrapie-infected experimental rodent models were tested by Western blot, including agents 263K-infected hamsters, 139A-, ME7-, and(More)
The title compound, C14H14BrNO4, contains a tricyclic ring system including three contiguous stereocenters all of which exhibit an R configuration. The cyclo-hexa-none ring adopts a chair conformation. The central oxane ring assumes a strained envelope conformation, with five of the ring atoms being nearly coplanar with the bromo-phenyl group and with the C(More)
OBJECTIVE To study the possible effect of tetracycline on protease-resistant activity in vitro and infectivity in vivo of a scrapie strain 263K. METHODS Scrapie pathogens were incubated with tetracycline at different concentrations for various periods of time and protease-resistant PrP signals were evaluated with proteinase K-treatment and Western blots.(More)
The promyelocytic leukemia (PML) gene is a tumor suppressor gene. It was first identified in acute promyelocytic leukemia, in which it is fused to retinoic acid receptor α by the (15;17) chromosomal translocation. The function of the PML protein is frequently lost or aberrant in human solid tumors. In human ovarian carcinoma tissue, PML detected by(More)
Methemoglobin concentration is an important pathophysiological biomarker, reflecting the oxygen-carrying and oxygen-releasing capabilities of hemoglobin (Hb). Raman spectroscopy is used to develop a novel technique for determining the methemoglobin concentration. Raman activity combined with two-dimensional correlation analysis is an attractive method for(More)
BACKGROUND We evaluated the features of neuropathology, abnormal prion protein (PrP) molecules, and clinical data of a Chinese woman diagnosed with familiar Creutzfeldt-Jakob disease (CJD), having 7 octa-repeats inserted with codon 129 methionine homozygote in the PRNP gene. METHODS Neuropathologic characteristics of the brain were analyzed by(More)