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LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500235-JLR200
LXR and PPAR activators regulate the expression of SULT2B1b, the key enzyme in the synthesis of CS, which is a potent regulator of epidermal differentiation and corneocyte desquamation. Expand
Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.
It is concluded that cardiac mAGPAT activity may be regulated by both the composition of m AGPAT isoforms and the levels of each isoform, as well as by PPARalpha activation. Expand
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism.
The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation. Expand
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
It is reported that both PPAR-gamma and -beta/delta activators markedly stimulate ABCA12 mRNA expression in cultured human keratinocyte (CHK) in a dose- and time-dependent manner, providing an additional mechanism by which PPAR and LXR activators promote epidermal permeability barrier homeostasis. Expand
Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology Published, JLR Papers in Press, January 8, 2008.
Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer. Expand
Ceramide Stimulates ABCA12 Expression via Peroxisome Proliferator-activated Receptor δ in Human Keratinocytes*
Ceramide, an important lipid component of epidermis, up-regulates ABCA12 expression via the PPARδ-mediated signaling pathway, providing a substrate-driven, feed-forward mechanism for regulating this key lipid transporter. Expand
Stratum corneum acidification is impaired in moderately aged human and murine skin.
  • E. Choi, M. Man, +8 authors T. Mauro
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 1 December 2007
It is reported that barrier defects in moderately aged humans or analogously aged mice are linked instead to defective stratum corneum (SC) acidity, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderate aged humans. Expand
Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S]
It is demonstrated that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte differentiation, with increased levels in the outer epidersmis, suggesting a potential role of ABCG 1 in permeability barrier homeostasis. Expand
LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation
  • Yan J. Jiang, D. Bikle
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular…
  • 1 October 2014
A novel mechanism for protection by VDR against skin cancer formation by maintaining the balance of oncogenic to tumor suppressing lncRNAs is found. Expand
PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis
It is reported that PPARgamma activators markedly stimulate AQP3 mRNA expression in both undifferentiated and differentiated cultured human keratinocytes (CHKs), providing an additional mechanism by which PPAR and LXR activators regulate epidermal function. Expand