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Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium
A new indole alkaloid with anti-inflammatory activity from Nauclea officinalis
17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 μM.
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
The investigation of the seeds of Strychnos nux-vomica led to the isolation of two novel indole alkaloids, strynuxlines A (1) and B (2), with an unprecedented 6/5/9/6/7/6 hexacyclic ring system.
Carbazole Alkaloids with Potential Neuroprotective Activities from the Fruits of Clausena lansium.
Findings indicate that regular consumption of the fruits of C. lansium may help people prevent the occurrence of Parkinson's disease and the separation and identification of these carbazole alkaloids possessing remarkable neuroprotective effects from the fruit could be extremely important to the discovery of new agents for the prevention and treatment of Parkinson’s disease.
Prenylated Coumarins from the Fruits of Manilkara zapota with Potential Anti-inflammatory Effects and Anti-HIV Activities.
The results suggest that appropriate and reasonable consumption of the fruits of M. zapota might assist people to prevent and reduce the occurrence of inflammatory diseases together with the infection of HIV and could be of great significance to the research and development of new natural anti-inflammatory and anti-HIV agents.
Cytotoxic indole alkaloids from Nauclea orientalis
Nauclorienine was a new indole alkaloid holding a rare corynanthe-type skeleton, and alkaloids 1–4 exhibited significant inhibitory effects against various human cancer cell lines with IC50 values comparable to those of cisplatin.
A new monoterpenoid indole alkaloid from Ochrosia elliptica
A new monoterpenoid indole alkaloid, 10-methoxyakuammidine, together with four known alkaloids, were isolated from the stems and leaves of Ochrosia elliptica and exhibited inhibitory effects with IC50 values comparable to those of cisplatin.
Neuroprotective carbazole alkaloids from the stems and leaves of Clausena lenis
A previously undescribed carbazole alkaloid, clausenalenine A, along with seven known analogues, were isolated from C. lenis for the first time and showed significant neuroprotective effects against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells in vitro.