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Three-dimension technologies offer great promise in providing improvements in the overall circuit performance. Physical design plays a major role in the ability to exploit the flexibilities offered in the third dimension, and this article gives an overview of placement and routing methods for FPGA- and ASIC-style designs. We describe CAD techniques for(More)
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs in human cell culture with a titration-invariant similarity score (TISS). This method successfully(More)
The large size of modern FPGAs has caused researchers to consider deploying hierarchical techniques in their design. In this paper, we consider the floorplanning of FPGAs. We present a two-step approach for the floorplanning of modern FPGAs that we believe is cleaner and more versatile than recent floorplanners. The steps, based on resource-aware fixed(More)
The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin is a concentration-limiting component of the β-catenin destruction complex, and its stability is regulated by tankyrase. However, the molecular mechanism by which(More)
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus acutely inhibiting the traffic emanating from the endoplasmic reticulum. Like(More)
In this paper, we consider general two-way relay networks (TWRNs) with two source and N relay nodes when neither the source nodes nor the relay nodes have access to channel-state information (CSI). A distributed differential space time coding with analog network coding (DDSTC-ANC) scheme is proposed. A simple blind estimation and a differential signal(More)
Fixed-die floorplanning is an important problem in the modern physical design process. An effective floorplanning algorithm is crucial to improving both the quality and the time-to-market of the design. In this paper, we present an analytical floorplanning algorithm that can be used to efficiently pack soft modules into a fixed die. The locations and sizing(More)
Inspired by the usefulness of small molecules to study membrane traffic, we used high-throughput synthesis and phenotypic screening to discover secramine, a molecule that inhibits membrane traffic out of the Golgi apparatus by an unknown mechanism. We report here that secramine inhibits activation of the Rho GTPase Cdc42, a protein involved in membrane(More)
This paper presents algorithms for a constrained version of the "modern" floorplanning problem proposed by Kahng in "Classical Floorplanning Harmful?" (Kahng, 2000). Specifically, the constrained modern floorplanning problem (CMFP) is suitable when die-size is fixed, modules are permitted to have rectilinear shapes and, in addition, the approximate relative(More)
Ubiquitination is an essential post-translational modification that mediates diverse cellular functions. SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) belongs to the Nedd4 family of HECT ubiquitin ligases that directly catalyzes ubiquitin conjugation onto diverse substrates. As a result, SMURF1 regulates a great variety of cellular physiologies(More)