Yan Chu

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Data cubes are widely used as a powerful tool to provide multi-dimensional views in data warehousing and On-Line Analytical Processing (OLAP). However, with increasing data sizes, it is becoming computationally expensive to perform data cube analysis. The problem is exacerbated by the demand of supporting more complicated aggregate functions (e.g.(More)
DNA methylation is a crucial epigenetic modification of the genome which is involved in embryonic development, transcription, chromatin structure, X chromosome inactivation, genomic imprinting and chromosome stability. Consistent with these important roles, DNA methylation has been demonstrated to be required for vertebrate early embryogenesis and essential(More)
Down syndrome (DS), caused by triplication of human chromosome 21, is the most common aneuploidies. The main characteristic of DS patients is intellectual disability. MicroRNAs (miRNAs) play important regulatory roles in various biological processes, such as embryonic development, cell differentiation, proliferation and apoptosis. Several miRNAs have shown(More)