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Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion
- Yixin Xu, Xuehan Li, Yan Cheng, Mingan Yang, Rurong Wang
- Biology, MedicineFASEB journal : official publication of the…
- 18 October 2020
It is delineated that IR‐induced ferroptotic cell death in lung tissue and ACSL4 were correlated with this process, and inhibition of Ferroptosis‐specific inhibitor, liproxastin‐1 (Lip‐1), and AC SL4 modulation in a preventive regimen mitigated the ferroPTotic damage in IR‐ induced lung injury.
Erythropoietin Promotes the Protective Properties of Transplanted Endothelial Progenitor Cells Against Acute Lung Injury via PI3K/Akt Pathway
Erythropoietin improved the survival and proliferation of transplanted EPCs and recruited them to the injured sites to exert their repairing functions, and the combination of EPO and EPC treatment may be a promising cell-based therapy for ALI patients.
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: The role of endothelial nitric oxide synthase
- Lei Lv, Shi-sen Jiang, Jun Xu, J. Gong, Yan Cheng
- BiologyClinical and experimental pharmacology…
- 1 January 2012
The aim of the present study was to determine whether ligustrazine exerts a cardioprotective effect during myocardial ischaemia reperfusion, and to investigate the underlying mechanisms and the role of endothelial nitric oxide synthase (eNOS) inCardioprotection.
Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.
Association of Serum Periostin with Cardiac Function and Short-Term Prognosis in Acute Myocardial Infarction Patients
Serum periostin was in negative correlation with LVEF and LAD, in positive association with Killip class and higher serum periOSTin level may be predictive for worse short-term disease prognosis indicated as more composite cardiovascular events six months post AMI.
Resveratrol activates endogenous cardiac stem cells and improves myocardial regeneration following acute myocardial infarction
Treatment with resveratrol increased the number of endogenous Sca-1+ CSCs in heart tissue after 7 days and significantly increased left ventricle (LV) function 4 weeks after AMI, as determined by an increase in LV fractional shortening.
Potential mechanism for endothelial progenitor cell therapy in acute myocardial infarction: Activation of VEGF- PI3K/Akte-NOS pathway.
- Yan Cheng, S. Jiang, Ruoyu Hu, Lei Lv
- Biology, MedicineAnnals of clinical and laboratory science
- 21 September 2013
The study suggests that EPC transplantation improves cardiac function after MI, mediated at least partially by activation of the VEGF -PI3K/Akt-eNOS pathway.
Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice.
Erythropoietin improves the efficiency of endothelial progenitor cell therapy after myocardial infarction in mice: effects on transplanted cell survival and autologous endothelial progenitor cell…