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In order to better constrain the tectonic evolution of central Asia under the influence of the India–Asia collision, we carried out a magnetostratigraphic study at the Kuitun He section, on the northern flank of the Tianshan range (northwest China). A total of 801 samples were collected from a 1559-m-thick section, which is composed mainly of(More)
We report a magnetostratigraphic and rock magnetic study of the Yaha section, located on the southern flank of the central Tian Shan mountains, Asia. Our results show a twofold increase in sedimentation rate as well as marked changes in rock magnetic characteristics ca. 11 Ma. After 11 Ma, sedimentation rate remained remarkably constant until at least 5.2(More)
This study examined neurocognitive deficits as familial vulnerability factors to schizophrenia. Twenty-three Chinese schizophrenic patients, 21 of their non-psychotic siblings and 26 healthy volunteers, matched for age, sex and education, were assessed by using a battery of neurocognitive tests including: Wisconsin Card Sorting Test (WCST), semantic verbal(More)
Repeated administration of opioids not only leads to tolerance and dependence, but also results in nociceptive enhancement called opioid-induced hyperalgesia (OIH). Nociceptive mediators involved in OIH generation remain poorly understood. In the present study, we tested the hypothesis that Ca(2+)/calmodulin-depent protein kinase II (CaMKIIalpha) is(More)
Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal death and synaptic degeneration. These(More)
We have previously demonstrated that the globular head of the hemagglutinin (HA) antigen fused to flagellin of Salmonella typhimurium fljB (STF2, a TLR5 ligand) elicits protective immunity to H1N1 and H5N1 lethal influenza infections in mice (Song et al., 2008, PLoS ONE 3, e2257; Song et al., 2009, Vaccine 27, 5875-5888). These fusion proteins can be(More)
Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two 'PPXY' motifs, that direct it to degradation in lysosomes. These signals are(More)
Vulnerability analysis is indispensably the first step towards securing a network protocol, but currently remains mostly a best effort manual process with no completeness guarantee. Formal methods are proposed for vulnerability analysis and most existing work focus on security properties such as perfect forwarding secrecy and correctness of authentication.(More)
BACKGROUND The purpose of this study was to evaluate the antitumor effect of cell-penetrating peptide-coated tripterine-loaded nanostructured lipid carriers (CT-NLC) on prostate tumor cells in vitro and in vivo. METHODS CT-NLC were developed to improve the hydrophilicity of tripterine. The antiproliferative effects of CT-NLC, tripterine-loaded(More)
The Tarim and Junggar basins in central Asia are capped by a thick pile of conglomerates, called the Xiyu Formation, that are commonly linked to a change in climate and/or accelerated uplift near the Plio-Pleistocene boundary. In order to better understand their origin and significance, we carried out a combined structural and magnetostratigraphic study in(More)