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Introduction Articular cartilage (AC) is frequently damaged as a result of trauma and degenerative diseases. AC hardly heals and its alteration often leads to further extracellular matrix (ECM) degradation and ultimately, to the loss of joint function. Human adipose-derived stem cells (hATSC) have recently been contemplated as reparative cells for(More)
OBJECTIVE A defect of the lysosomal enzyme alpha-L-iduronidase (IDUA) interrupts the degradation of glycosaminoglycans in mucopolysaccharidosis type I, causing severe neurological manifestations in children with Hurler's syndrome. Delivery of the missing enzyme through stereotactic injection of adeno-associated virus vectors coding for IDUA prevents(More)
BACKGROUND Entamoeba histolytica is an important parasite of the human intestine. Its life cycle is monoxenous with two stages: (i) the trophozoite, growing in the intestine and (ii) the cyst corresponding to the dissemination stage. The trophozoite in the intestine can live as a commensal leading to asymptomatic infection or as a tissue invasive form(More)
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