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OBJECTIVE To explore the expression levels and clinical significance of cyclin D1 and estrogen receptor (ER) in breast cancer. METHODS Immunohistochemical staining was performed to detect the expression levels of cyclin D1 and ER in 102 breast cancers and 60 normal breast tissue specimens. Referring to clinicopathological parameters and 5-year follow-up(More)
Downregulation of p57(Kip2) is involved in tumor progression, and S-phase kinase-associated protein 2 (Skp2) is an E3 ligase that regulates a variety of cell cycle proteins. However, the prognostic value of p57(Kip2) and its correlation with Skp2 in breast cancer have not been fully elucidated. Here we report our study on the expression of p57(Kip2) and(More)
Epithelial-to-mesenchymal transition (EMT) plays a crucial role in the progression of renal interstitial fibrosis, which finally leads to renal failure. Erbin, a member of LAP family, is recently reported to inhibit Smads and ERK pathway which are two important types of intracellular signaling involved in TGF-β1-induced EMT. However, the role of Erbin in(More)
Cdc42-interacting protein-4 (CIP4) is an F-BAR (Fer/CIP4 and Bin, amphiphysin, Rvs) family member that regulates membrane deformation and endocytosis, playing a key role in extracellular matrix (ECM) deposition and invasion of cancer cells. These processes are analogous to those observed during the initial epithelial-mesenchymal transition (EMT) of renal(More)
BACKGROUND/PURPOSE Ischemic stroke is characterized by high morbidity and mortality worldwide. Matrix metalloproteinase 2 (MMP2), aquaporin (AQP) 4, and AQP9 are linked to permeabilization of the blood-brain barrier (BBB) in cerebral ischemia/reperfusion injury (CIRI). BBB disruption, tissue inflammation, and MMP/AQP upregulation jointly provoke brain(More)
A series of solvents with different solubilities for DR3TBDTT and PC71 BM, and different boiling points, is used for solvent vapor annealing (SVA) treatment to systematically investigate the solvent-morphology-performance relationship. The presence of solvent molecules inside bulk-heterojunction (BHJ) thin films promotes the mobility of both donor and(More)
BACKGROUND LCL161, a novel Smac mimetic, is known to have anti-tumor activity and improve chemosensitivity in various cancers. However, the function and mechanisms of the combination of LCL161 and paclitaxel in non-small cell lung cancer (NSCLC) remain unknown. METHODS Cellular inhibitor of apoptotic protein 1 and 2 (cIAP1&2) expression in NSCLC tissues(More)
UNLABELLED Down-regulation of p57 (KIP2) cyclin-dependent kinase inhibitors accelerates the growth and invasion of hepatocellular carcinoma (HCC), suggesting that p57 may play an important role in liver carcinogenesis. However, the mechanism or oncogenic signal leading to p57 down-regulation in HCC remains to be determined. Herein, we demonstrated that(More)
BACKGROUND Acute kidney injury (AKI) impacts the survival of liver transplant recipients severely. To date, the related mechanism and effective therapy have not been rigorously explored. The present study aimed to explore the role of p53-mediated autophagy in the protective effect of hydrogen-rich saline (HRS) on AKI after orthotropic liver transplantation(More)
Base on actual project and consider geometric nonlinearity and material nonlinearity of structure, the numeric model of long-span continuous rigid frame bridge with high piers is built by using the current FEM software ANSYS. On the basis of the study of sensors optimization placement for bridge, real-time monitoring to different construction stages and(More)