Yamileth Nicolau

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BACKGROUND The Björnstad syndrome, an autosomal recessive disorder associated with sensorineural hearing loss and pili torti, is caused by mutation of a previously unidentified gene on chromosome 2q34-36. METHODS Refined genetic mapping and DNA sequencing of 44 genes between D2S2210 and D2S2244 revealed BCS1L mutations. Functional analyses elucidated how(More)
OBJECTIVE Butterfly graft inlay tympanoplasty is a well-established technique for the repair of small perforations. However, the efficacy of the technique for medium and large tympanic membrane perforations remains unknown. STUDY DESIGN Retrospective case series. METHODS Postauricular tympanoplasty and tympanomastoidectomy using a large butterfly(More)
n engl j med 361;12 nejm.org september 17, 2009 1216 teroid therapy, used in the protocols of the studies conducted by Tydén et al. and van den Hoogen and Hilbrands, could suppress the effects of cytokine release, which would explain why the increase in acute rejection seen in our corticosteroid-free protocol was not observed in the other studies.(More)
Cembranoids are cyclic diterpenoids found in tobacco and in marine invertebrates. The present study established that tobacco cembranoids inhibit behavioral sensitization to nicotine in rats and block several types of nicotine acetylcholine receptors (AChRs). 1) At the behavioral level, rat locomotor activity induced by nicotine was significantly increased(More)
HYPOTHESIS The study of infant temporal bones with tuberculosis (TB) of the middle ear and mastoid could provide information to assist with clinical diagnosis in this population. BACKGROUND The TB pandemic has become a critical global public health problem. With the rising incidence of the disease, otolaryngologists might encounter an increased frequency(More)
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