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Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria
TLDR
Evaluated the antibacterial activity of two peptides developed by solid-phase synthesis, Alyteserin 1c (WT) and its mutant derivative (ΔM), which shows increased net charge and reduced hydrophobicity, and determined that the helical stability of the peptide is indispensable for antimicrobial activity. Expand
Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides
TLDR
This review focuses on the current status of research in peptides with dual antimicrobial–anticancer activity, including advances in computational biology using in silico analyses as a powerful tool for the study and rational design of these types of peptides. Expand
A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa
TLDR
Investigation of the in vitro antibacterial effect of a short synthetic CAMP derived from the ΔM2 analog of Cec D-like against clinical isolates of K pneumoniae and P aeruginosa revealed a bactericidal effect of CAMP-CecD against both wild-type and resistant strains, but MDR P aerUGinosa showed higher susceptibility to this peptide. Expand
In Silico Discovery of Antimicrobial Peptides as an Alternative to Control SARS-CoV-2
TLDR
New potentially effective AMPs with antiviral properties for SARS-CoV-2 were identified, but they need experimental validation for their therapeutic effectiveness. Expand
In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes
TLDR
A series of lanthanide complexes, including Schiff base ligands derived from 1H-benzimidazol-2-yl)aniline, salicylaldehyde, and 2,4-dihydroxybenzaldehyde were synthesized and characterized using different spectroscopic methods and exhibited notable effect on model membranes imitating mammalian and bacterial membranes and rolled along DNA strands through groove interactions. Expand
Antimicrobial Contribution of Chitosan Surface-Modified Nanoliposomes Combined with Colistin against Sensitive and Colistin-Resistant Clinical Pseudomonas aeruginosa
TLDR
Interestingly, the free coated nanoliposomes exhibited the same antibacterial activity in both sensitive and MDR strains, and it was determined that colistin is weakly associated with micelles constituted by zwitterionic phospholipids. Expand
A Study of the Interaction of a New Benzimidazole Schiff Base with Synthetic and Simulated Membrane Models of Bacterial and Mammalian Membranes
TLDR
A new Schiff base (Bz-Im) derivative from 2-(m-aminophenyl)benzimidazole and 2,4-dihydroxybenzaldehyde was synthesized and characterized by spectroscopic and spectrometric techniques, and results showed that, at low compound concentrations, the effects were similar in both membrane models. Expand
In Silico Characterization of the Interaction between the PBP2a “Decoy” Protein of Resistant Staphylococcus aureus and the Monomeric Units of Eudragit E-100 and Poly(Maleic Acid-alt-Octadecene)
TLDR
Molecular coupling studies were carried out in the active site of the PBP2a protein with the monomeric units of both polymers in neutral and ionized form, as well as with ampicillin antibiotic (model β-lactam drug). Expand
In Silico Selection and Evaluation of Pugnins with Antibacterial and Anticancer Activity Using Skin Transcriptome of Treefrog (Boana pugnax)
TLDR
In order to combat bacterial and cancer resistance, peptides (pugnins) with dual antibacterial l–anticancer activity from the Boana pugnax skin transcriptome were identified through in silico analysis and screened for antimicrobial activity. Expand