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PURPOSE Adjuvant folinic acid, fluorouracil, and oxaliplatin (FOLFOX) chemotherapy for resected high-risk colon cancer is associated with a low risk of febrile neutropenia (FN). Neutropenia, however, is a common cause of dose modification or delay with unknown consequences on outcomes. We examined the effect of neutropenia-related and other dose-limiting(More)
BACKGROUND Epistasis is recognized fundamentally important for understanding the mechanism of disease-causing genetic variation. Though many novel methods for detecting epistasis have been proposed, few studies focus on their comparison. Undertaking a comprehensive comparison study is an urgent task and a pathway of the methods to real applications. (More)
Intracellular accumulation of wild-type tau is a hallmark of sporadic Alzheimer's disease (AD), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. Here we found that overexpression of human wild-type full-length tau (termed hTau) induced memory deficits with impairments of synaptic plasticity.(More)
Great efforts have been devoted to alleviate uncertainty of detected cancer genes as accurate identification of oncogenes is of tremendous significance and helps unravel the biological behavior of tumors. In this paper, we present a differential network-based framework to detect biologically meaningful cancer-related genes. Firstly, a gene regulatory(More)
We demonstrate an electrostatic surface guiding for cold polar molecules over a long distance of 44.5 cm, 0.85 mm above a dielectric substrate, and measure the transverse distribution of the guided supersonic D2O/CH3Br beam and its longitudinal velocity one. Also, we study the dependence of the relative guiding efficiency and the transverse temperature of(More)
The aim of the present study was to explore whether an ultra-filtration extract from Xin Mai Jia (XMJ), a Chinese medicinal formulation, has a protective effect on human aortic smooth muscle cell (HASMC) injury models induced by hydrogen peroxide (H 2 O 2), and to consider the mechanism and efficacy of the therapeutic action of XMJ on atherosclerosis.(More)
Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer's disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a significant reduction of α4 subunit of nicotinic acetylcholine(More)
We experimentally demonstrate a compact, all-solid-state 532 nm semi-Gaussian laser beam (SGB) source based on a 1064 nm laser and a transversely varying periodically-poled LiTaO3 (TPPLT) crystal as the laser beam shaper as well as the nonlinear frequency converter. We have used the designed TPPLT crystal to obtain a neat 532nm SGB with the quality of(More)
We demonstrate electrostatic guiding of cold heavy water (D(2)O) molecules over a distance of 44.5 cm by using a quadrupolelike electrostatic field, which is generated by the combination of two parallel charged poles and two grounded metal plates. We measure the transverse spatial distribution of the guided D(2)O molecular beam and study the dependence of(More)