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Twin-Spot MARCM to reveal developmental origin and identity of neurons
A comprehensive understanding of the brain requires the analysis of individual neurons. We used twin-spot mosaic analysis with repressible cell markers (twin-spot MARCM) to trace cell lineages atExpand
Modularized functions of the Fanconi anemia core complex.
This work reveals the roles of several FA gene products with previously undefined functions and a modularized assembly of the FA core complex. Expand
Endodomain Diversity in the Drosophila Dscam and Its Roles in Neuronal Morphogenesis
Dscam with or without exon 19 in its endodomain is used to govern different stage-specific neuronal morphogenetic processes, possibly due to differences in protein targeting. Expand
The bHLH Repressor Deadpan Regulates the Self-renewal and Specification of Drosophila Larval Neural Stem Cells Independently of Notch
It is demonstrated that the Hairy and Enhancer-of-Split family protein Deadpan (Dpn) plays important roles in maintaining NB self-renewal and specification of type II NBs in larval brains and that Dpn and Notch function independently in regulating type II NB proliferation and specification. Expand
Nuclear Receptor Unfulfilled Regulates Axonal Guidance and Cell Identity of Drosophila Mushroom Body Neurons
It is found that unfulfilled (unf), an ortholog of human photoreceptor specific nuclear receptor (PNR), regulates axonal morphogenesis and neuronal subtype identity in mushroom bodies by knocking down individual NRs by targeted RNAi. Expand
Emerging roles of lysine methylation on non-histone proteins
This review will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysines methylation and other PTMs in regulating the functions of the modified proteins. Expand
PtdIns(4,5)P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance
A coincidence detection mechanism regulates phagosomal sealing and couples it with phosphoinositide conversion from PtdIns(4,5)P2 enrichment on unsealed phagosomes to PtdIns3P enrichment on fullyExpand
Extremes of Lineage Plasticity in the Drosophila Brain
It is proposed that in the intrinsic mushroom body neuron lineage, the numbers for each class are highly plastic, depending on the timing of temporal fate transitions and the rate of neuroblast proliferation, given their respective roles as parallel processors versus discrete carriers of olfactory information. Expand
Making Drosophila lineage–restricted drivers via patterned recombination in neuroblasts
New genetic tools that target neuroblasts and their diverse descendants are developed, increasing the ability to study fly brain structure and development and converting conventional drivers that are temporarily expressed in neuroblast, into drivers expressed in all subsequent neuroblast progeny. Expand
An Enhanced Gene Targeting Toolkit for Drosophila: Golic+
Golic+ realizes high-efficiency ends-out gene targeting in ovarian cystoblasts, which can be readily scaled up to achieve high-throughput genome editing. Expand