Yalan Deng

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Insulin resistance is a major hallmark of metabolic syndromes, including Type 2 diabetes. Although numerous functions of SGK1 (serum- and glucocorticoid-regulated kinase 1) have been identified, a direct effect of SGK1 on insulin sensitivity has not been previously reported. In the present study, we generated liver-specific SGK1-knockout mice and found that(More)
Feature selection is a process which chooses a subset from the original feature set according to some rules. The selected feature retains original physical meaning and provides a better understanding for the data and learning process. However, few modern feature selection approaches take the advantage of features’ context information. Based on this(More)
Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role of hypothalamic ATF4 in the regulation of energy homeostasis is poorly understood. In this study, we showed that hypothalamic proopiomelanocortin (POMC) neuron-specific ATF4 knockout (PAKO) mice are lean and have higher energy expenditure.(More)
Although many functions of activating transcription factor 4 (ATF4) are identified, a role of ATF4 in the hypothalamus in regulating energy homeostasis is unknown. Here, we generated adult-onset agouti-related peptide neuron-specific ATF4 knockout (AgRP-ATF4 KO) mice and found that these mice were lean, with improved insulin and leptin sensitivity and(More)
BACKGROUND Chemo-resistance is a leading cause of tumor relapse and treatment failure in patients with ovarian cancer. The identification of effective strategies to overcome drug resistance will have a significant clinical impact on the disease. METHODS The protein and mRNA expression of GOLPH3L in ovarian cancer cell lines and patient tissues were(More)
Title: MiR-216b inhibits cell proliferation by targeting FOXM1 in cervical cancer cells and is associated with better prognosis Authors: Shanyang He (hsy5g777@sina.com) Bing Liao (bingl168@163.com) Yalan Deng (1450101649@qq.com) Chang Su (suchang@21cn.com) Jiuling Tuo (452069764@qq.com) Jun Liu (Junliuzhshy@163.com) Shuzhong Yao (yszlfy@163.com) Lin Xu(More)
Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown. Here, we showed that mice lacking IRE1α specifically in POMC neurons (PIKO) are lean and resistant to high-fat diet-induced obesity and obesity-related(More)
Long non-coding RNA SNHG20 has been demonstrated as playing crucial regulatory roles in a many types of cancer. However, the biological function of lncRNA SNHG20 in ovarian cancer are still unclear. In this study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer(More)
Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated the relationships between miR-216b and FOXM1 and the role of miR-216b in cell proliferation and prognosis of cervical cancer patients. Western(More)