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Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids.
E. coli strains capable of high-level flavonoid synthesis through traditional metabolic engineering techniques are developed and demonstrated the efficient and scalable production of plant flavonoids from E. coli for pharmaceutical and nutraceutical applications.
Conversion of proteins into biofuels by engineering nitrogen flux
The results show the feasibility of using proteins for biorefineries, for which high-protein microalgae could be used as a feedstock with a possibility of maximizing algal growth and total CO2 fixation.
Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
A novel pathway is established and an E. coli strain is constructed for the production of caffeic acid and it is identified that TAL is the rate-limiting enzyme in this pathway.
Enantioselective synthesis of pure (R,R)-2,3-butanediol in Escherichia coli with stereospecific secondary alcohol dehydrogenases.
We characterized the activity and stereospecificity of four secondary alcohol dehydrogenases (sADHs) towards acetoin reduction and constructed synthetic pathways in E. coli to produce…
Dehydratase mediated 1-propanol production in metabolically engineered Escherichia coli
It is speculated that dragging more carbon flux towards methylglyoxal by manipulating glycolytic pathway and eliminating competing pathways such as lactate generation can further enhance the production of 1-propanol.
Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products.
Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli.
Extending shikimate pathway for the production of muconic acid and its precursor salicylic acid in Escherichia coli.
Biosynthesis of Natural Flavanones in Saccharomyces cerevisiae
- Yajun Yan, Abhijeet Kohli, M. Koffas
- Biology, EngineeringApplied and Environmental Microbiology
- 1 September 2005
A four-step flavanone biosynthetic pathway was constructed and introduced into Saccharomyces cerevisiae and produced the flavanones naringenin and pinocembrin 62 and 22 times more efficiently compared to previously reported recombinant prokaryotic strains.
Engineering metabolic systems for production of advanced fuels
The four major metabolic systems, the coenzyme-A mediated pathways, the keto acid pathways,The fatty acid pathway, and the isoprenoid pathways, that allow production of these fuel-grade chemicals are reviewed.