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The Gate of the Influenza Virus M2 Proton Channel Is Formed by a Single Tryptophan Residue*
The influenza virus M2proton-selective ion channel is known to be essential for acidifying the interior of virions during virus uncoating in the lumen of endosomes. The M2 protein is a homotetramerExpand
Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6.
Glutaredoxins (Grxs) are a ubiquitous family of proteins that reduce disulfide bonds in substrate proteins using electrons from reduced glutathione (GSH). The yeast Saccharomyces cerevisiae Grx6 is aExpand
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis. Mitophagy is regulated by the post-translational modification ofExpand
Solution Structure of Human Peptidyl Prolyl Isomerase-like Protein 1 and Insights into Its Interaction with SKIP*
The human PPIL1 (peptidyl prolyl isomerase-like protein 1) is a specific component of human 35 S U5 small nuclear ribonucleoprotein particle and 45 S activated spliceosome. It is recruited by SKIP,Expand
Crystal structure of the yeast cytoplasmic thioredoxin Trx2
Rui Bao, Yuxing Chen,* Ya-Jun Tang, Joel Janin, and Cong-Zhao Zhou* Protein Research Institute, Tongji University, Shanghai 200092, People’s Republic of China Hefei National Laboratory for PhysicalExpand
Structural basis for the different activities of yeast Grx1 and Grx2.
Yeast glutaredoxins Grx1 and Grx2 catalyze the reduction of both inter- and intra-molecular disulfide bonds using glutathione (GSH) as the electron donor. Although sharing the same dithiolic CPYCExpand
Binding model of human coactosin-like protein with filament actin revealed by mutagenesis.
Human coactosin-like protein (CLP) is a small (MW approximately 17 kDa) evolutionarily conserved actin-binding protein. It can bind to actin filaments but not globular actin and belongs to the fourthExpand
Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3.
The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor ofExpand
Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila
Abstract In Drosophila, dosage compensation globally upregulates the expression of genes located on male single X-chromosome. Maleless (MLE) helicase plays an essential role to incorporate the roXExpand
Solution structure of human SUMO-3 C47S and its binding surface for Ubc9.
Small ubiquitin-related modifier SUMO-3 is a member of a growing family of ubiquitin-like proteins (Ubls). So far, four isoforms of SUMO have been identified in humans. It is generally known thatExpand
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