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The Gate of the Influenza Virus M2 Proton Channel Is Formed by a Single Tryptophan Residue*
TLDR
The results indicate that gating of the M2 ion channel is governed by a single side chain at residue 41 of the TM domain and that this property is mediated by an indole moiety.
Solution Structure of Human Peptidyl Prolyl Isomerase-like Protein 1 and Insights into Its Interaction with SKIP*
TLDR
The results illustrated that a novel cyclophilin-protein contact mode exists in the PPIL1-SKIP complex during activation of the spliceosome, and the biological implication of this binding with splICEosome rearrangement during activation is discussed.
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
TLDR
The structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selectiveMitophagy.
Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.
TLDR
Results are consistent with the hypothesis that the loss of alpha3Cx46 leads to increased levels of Ca2+ ions, and this increase activates the CAPN3 isoform, Lp82/85, which results in the formation of a nuclear cataract.
Structure-guided activity enhancement and catalytic mechanism of yeast grx8.
TLDR
NMR chemical shift perturbation analyses combined with GSH analogue inhibition assays enabled to elucidate that wild-type Grx8 and all mutants adopt a ping-pong mechanism of catalysis, and provide structural insights into the catalytic mechanism of dithiol Grxs.
Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila
TLDR
This research provides structural insights into the interactions between MLE dsRBDs and R2H1 and facilitates a deeper understanding of the mechanism by which MLE tandem ds RBDs play an indispensable role in specific recognition of roX and the assembly of the MSL-DCC in Drosophila dosage compensation.
Solution structure of human SUMO-3 C47S and its binding surface for Ubc9.
TLDR
This work indicates dissimilarities between SUMO-3 andsumO-1 in tertiary structure and provides insight into the specific interactions of SUMO -3 with its modifying enzyme.
Identification of proteins that modify cataract of mouse eye lens
TLDR
The results show HSP27/25 and/or ERp29 are the likely major modifying factors for cataractogenesis, and suggests that small heat‐shock proteins have a major role for influencingCataract formation in humans.
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