Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.
- Yajuan Zhang, Guanzhen Yu, Weiwei Yang
- Biology, ChemistryMolecules and Cells
- 1 July 2018
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development.
- Xiongjun Wang, Ruilong Liu, Weiwei Yang
- Biology, ChemistryMolecules and Cells
- 3 October 2019
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
- Ruilong Liu, Wenfeng Li, Weiwei Yang
- Biology, ChemistryNature Communications
- 1 March 2019
It is shown that activation of EGFR induces phosphorylation of this enzyme at Y481 to activate the pentose phosphate pathway, which consequently reduces ROS and accelerates DNA synthesis to promote tumor growth and radioresistance.
Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking
- Guang-Zhi Jin, Yajuan Zhang, Weiwei Yang
- Biology, ChemistryPLoS Biology
- 1 October 2018
It is shown that PGM1 is down-regulated in hepatocellular carcinoma (HCC), which is associated with the malignancy and poor prognosis of HCC, and a novel regulatory mechanism of PGM 1 expression is uncovered.
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy
- Yajuan Zhang, Y. Sun, Zheng Zhang
- Biology, MedicineCellular Physiology and Biochemistry
- 28 November 2018
150Rik, an evolutionarily conserved lncRNA, was significantly upregulated in renal tissue of db/db DN mice and in mesangial cells (MCs) cultured under a high glucose condition, and overexpression or knockdown of 150Rik was found to regulate cell proliferation in MCs.
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
- Yajuan Zhang, Hua Yu, Weiwei Yang
- BiologyJournal of Clinical Investigation
- 1 November 2021
This work shows that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhancedPHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine.
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion
- Yajuan Zhang, Ming Zhao, Weiwei Yang
- BiologyNature Metabolism
- 1 March 2022
The findings show a mechanism through which phosphorylation-dependent subcellular translocation of PDHE1α promotes tumour immune evasion and synergy activation of NF-κB and reactive oxygen species detoxification promote tumour cell survival and enhances resistance to cytotoxic lymphocytes.
Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis
- Wencheng Zhu, Huiying Chu, Weiwei Yang
- Biology, ChemistryCell Research
- 16 January 2023
The finding reveals a previously unrecognized role of FBP1 as a protein phosphatase and establishes the critical role ofFBP1-mediated IκBα dephosphorylation in colorectal tumorigenesis.
To Determine Pivotal Genes Driven by Methylated DNA in Obstructive Sleep Apnea Hypopnea Syndrome
- Yan Li, Yajuan Zhang
- BiologyComput. Math. Methods Medicine
- 2021
This study downloads the OSAHS data from the GEO database and reveals 520 hypermethylated genes and 889 hypomethylated genes that exhibited an association with the regulation of angiogenesis, apoptosis, Wnt, and ERBB2 signaling pathways, and offers a new hint of understanding the molecular mechanisms in OSA HS progression.
...
...