Oxidative stress is implicated in tissue inflammation, and plays an important role in the pathogenesis of immune-mediated nephritis. Using the anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM-GN) mouse model, we found that increased expression of glutathione S-transferase Mu 2 (GSTM2) was related to reduced renal damage caused… (More)
In this paper, we construct a matrix, which transforms a generalized C-Bézier basis into a generalized uniform algebraic-trigonometric B-spline (C-B-spline or UAT B-spline) basis. We also show that it is a totally positive matrix and give a normalized B-basis of the generalized UAT B-splines.
C-Bézier and C-B-spline curves, as the trigonometric extensions of cubic uniform spline curves are well-known in geometric modeling. These curves depend on a shape parameter α in a way that α → 0 yields the cubic polynomial curves. The geometric effect of the alteration of this parameter is discussed in this paper by the help of relative parametrization and… (More)
Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based… (More)
GB-spline curves can be considered as the generalization of B-spline curve incorporating a shape parameter into the polynomial basis functions. The geometric effect of the alteration of the shape parameter is discussed in this paper, including constrained shape control of the curve.
Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1) gene… (More)
This paper presents a novel method to simplify stochastic workflow networks for their performance analysis under a unified computable framework. This method is based on two techniques: (1) module simplification, and (2) PH equivalence and PH approximation. In the first technique, simplified procedures for at least four crucial modules: sequential routing,… (More)
Mapping of DNase I hypersensitive sites (DHSs) is a powerful tool to experimentally identify cis-regulatory elements (CREs). Among CREs, enhancers are abundant and predominantly act in driving cell-specific gene expression. Krüppel-like factors (KLFs) are a family of eukaryotic transcription factors. Several KLFs have been demonstrated to play important… (More)
Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order to investigate whether exogenous CO can mediate the growth and proliferation of vascular cells, in this study, we used 250 parts per million (ppm) of CO to treat… (More)
Resource scheduling is a fundamental issue in achieving high performance on computational grids. In this paper, we concentrate on parallel resource scheduling problems for hierarchical resource scheduling architecture of computational grids, and propose a stochastic reward nets (SRN) based performability evaluation framework for evaluating the… (More)