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Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression
TLDR
ARLNC1 is a newly discovered lncRNA that is induced by androgen receptor (AR) and maintains AR signaling by stabilizing the AR transcript and is identified as a novel therapeutic target.
Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy.
TLDR
The first comprehensive molecular PeSCCA analysis is provided, which offers new insight into potential precision medicine approaches for this disease, including strategies targeting EGFR.
Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.
TLDR
This study identifies EZH2 as a critical epigenetic regulator of ADT resistance and defines ASO-based cotargeting of EZh2 and AR as a promising strategy for the treatment of CRPC.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.
TLDR
It is demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to interferon (IFN) responsive genes, caused impaired IFN-gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies as well as in murine cancer models.
MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions
TLDR
MechRNA is introduced, a pipeline for corroborating RNA–RNA interaction prediction and protein binding prediction for identifying possible lncRNA mechanisms involving specific targets or on a transcriptome-wide scale, allowing for large-scale analysis of lnc RNA interactions with little or no loss of optimality.
LncRNA H19 Overexpression in Endometriosis and its Utility as a Novel Biomarker for Predicting Recurrence
TLDR
LncRNA H19 may be involved in the pathogenesis of endometriosis especially in the mechanism of recurrence and is a novel potential predictor of the recurrence of endometricriosis.
Abstract 2458: The androgen receptor-regulated lncRNA landscape reveals a role forARlnc1in prostate cancer progression
TLDR
Transcriptome sequencing data support a role for ARlnc1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression, and identifies AR lnc1 as a novel therapeutic target.
Knockdown of lncRNA H19 suppresses endometriosis in vivo
TLDR
The Knockdown of lncRNA H19 suppresses endometriosis in vivo and further study is required to explore the underlying mechanism in the future.
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