Yafei Liu

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Clinical trials have reported the effects of Tripterygium wilfordii Hook F (TwHF) extracts (TEs) in the treatment of rheumatoid arthritis (RA); however, the results have been inconsistent. This meta-analysis is aimed to assess the safety of TEs and their effects on the treatment of RA. Randomised controlled trials (RCTs) comparing the effects of TEs and(More)
25-Hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound isolated from Panax ginseng, and its anti-tumor activity has been studied in previous publication. In the current study, we investigated the anti-tumor activity of three novel derivatives synthesized from 25-OH-PPD, namely (20R)-12β-O-(l-chloracetyl)-dammarane-3β, 20, 25-triol (xl),(More)
Introducing amide bonds into a steroid nucleus or its side chain may reduce the acute toxicity and enhance the pharmaceutical activity. In this work, a designed steroidal amide compound, named 3β-hydroxy-17-aza-d-homo-5-androsten-17-one (HAAO), was synthesized and identified. The interactions between HAAO and human serum albumin (HSA) were studied by(More)
Based on the evaluation method of grey comprehensive subordination degree, a new method of determining the weight for the variety regional test was proposed in accordance with the principle of maximum deviation in this paper. Using the method, the analysis was carried out for the regional test of winter wheat variety in the south of Huanhuai River valley in(More)
BACKGROUND Tetrahydrocurcumin (THC), an active metabolite of curcumin, has been reported to have similar biological effects to curcumin, but the mechanism of the antitumor activity of THC is still unclear. METHODS The present study was to investigate the antitumor effects and mechanism of THC in human breast cancer MCF-7 cells using the methods of MTT(More)
UNLABELLED The E7 oncoprotein of the high-risk human papillomavirus (HPV) plays a major role in HPV-induced carcinogenesis. E7 abrogates the G1 cell cycle checkpoint and induces genomic instability, but the mechanism is not fully understood. In this study, we performed RNA sequencing (RNA-seq) to characterize the transcriptional profile of keratinocytes(More)
Electric bus is one of the important demonstration types in the “Ten Cities, Thousand Vehicles” program of China. The total life cycle cost (TLCC) of electric bus was compared with traditional fuel bus. In the given year, the TLCC of electric bus and traditional fuel bus was made equaled to obtain the corresponding charging/swapping price. The(More)
The development of charging infrastructure not only affects the operating results of electric vehicles in demonstration cities, but also affects the purchase and use behavior of users. Based on literature and summary reports of demonstration cities, an assessment indicator system of 4 major factors and 13 observation indicators is developed on city(More)