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Epistasis is a ubiquitous phenomenon in genetics, and is considered to be one of the main factors in current efforts to detect missing heritability for complex diseases. Simulation is a critical tool in developing methodologies that can more effectively detect and study epistasis. Here we present a simulator, epiSIM (epistasis SIMulator), that can simulate(More)
A DNA computing model for solving graph vertex coloring problem is proposed in this article. To illustrate the capability of the DNA computing model, a 3-colorable graph with 61 vertices was constructed as an example. Using this model, more than 99% of false solutions were deleted when the initial solution space was established and finally all solutions of(More)
Through the analysis of the transit network solution of optimal path algorithm, this paper proposes the bus route optimization algorithm of DNA to consider both the shortest distance by bus and the minimum interchange, and gives a detailed biological process. It not only puts forward a new feasible algorithm for transit network optimal path search, but also(More)
Fixed-length three DNA Segments encoding is brought forward. Therefore, closed circle DNA computing model is extended. The same position of extended closed circle DNA is divided into three sections corresponding to three function areas. The three function areas are addition segment, filling segment and subtraction segment, so extended closed circle DNA(More)
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