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Recent progress in information extraction has shown how to automatically build large ontologies from high-quality sources like Wikipedia. But knowledge evolves over time; facts have associated validity intervals. Therefore, ontologies should include time as a first-class dimension. In this paper, we introduce Timely YAGO, which extends our previously built(More)
There have been major advances on automatically constructing large knowledge bases by extracting relational facts from Web and text sources. However, the world is dynamic: periodic events like sports competitions need to be interpreted with their respective timepoints, and facts such as coaching a sports team, holding political or business positions, and(More)
Epithelial-mesenchymal transition (EMT) is a key process that drives cancer invasion. Recently, hypoxia has been reported to induce EMT, accompanied by cytoskeleton remodeling. As RhoE is a key regulator in cytoskeleton formation, we hypothesized that RhoE may play a role in hypoxia-induced EMT. For the first time, we report that RhoE protein levels(More)
Krüppel-like factor 8 (KLF8), a downstream transcription factor of transforming growth factor-β1 (TGF-β1), has a role in tumorigenesis, tumor progress and epithelial-to-mesenchymal transition (EMT) induction. Recent studies mainly focused on its role in breast cancer and hepatocellular carcinoma; however, little is studied in gastric cancer. Here, we aim to(More)
Hypoxia has been implicated as a crucial microenvironmental factor that induces cancer metastasis. We previously reported that hypoxia could promote gastric cancer (GC) metastasis, but the underlying mechanisms are not clear. Long noncoding RNAs (lncRNAs) have recently emerged as important regulators of carcinogenesis that act on multiple pathways. However,(More)
BACKGROUND Acute kidney injury (AKI) has become a worldwide public health problem, but little information is available about the disease burden in China. We aimed to evaluate the burden of AKI and assess the availability of diagnosis and treatment in China. METHODS We launched a nationwide, cross-sectional survey of adult patients who were admitted to(More)
The Web and digitized text sources contain a wealth of information about named entities such as politicians, actors, companies, or cultural landmarks. Extracting this information has enabled the automated construction of large knowledge bases, containing hundred millions of binary relationships or attribute values about these named entities. However, in(More)
Previously, we reported that hypoxia was able to induce invasion and metastasis in gastric cancer and that hypoxia-inducible factor-1 (HIF-1) is a key factor involved in this tumor type. Krüppel-like factor 8 (KLF8) as a transcriptional repressor has been suggested as a promoter of tumor metastasis in breast cancer and an inducer of the(More)
A museum guide system which is based on handheld devices (e.g. PDAs, short for Personal Digital Assistants) is presented in this paper. Radio-frequency identification (RFID) is used to navigate and get the index number of exhibit. Compared to traditional guide systems, such as tape or CD guide machine, this system provides visitors good visual and audio(More)