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Under the ANDRA Meuse/Haute Marne underground research laboratory scientific programme, two boreholes (EST204 and EST205) were drilled to a depth of 510 m for the purposes of scientific characterization. Twenty-nine core samples were taken in borehole EST205 every 3 m between 422 and 504 m depth. Physical property measurements (water content, porosity,(More)
Vesicular monoamine transporter 2 (VMAT2) transports monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons. VMAT2 is a member of the DHA12 family of multidrug transporters that belongs to the major facilitator superfamily of secondary transporters. Tetrabenazine (TBZ) is a non-competitive inhibitor of(More)
The vesicular neurotransmitter transporter VMAT2 is responsible for the transport of monoamines into synaptic and storage vesicles. VMAT2 is the target of many psychoactive drugs and is essential for proper neurotransmission and survival. Here we describe a new expression system in Saccharomyces cerevisiae that takes advantage of the polyspecificity of(More)
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