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PURPOSE Because of concern for drug-induced cognitive dysfunction during clinical trials using substrate reduction therapy (miglustat) in type 1 Gaucher disease and because it has been suggested that some patients with type 1 Gaucher disease may develop neurocognitive impairment as part of the natural history, two different batteries of neuropsychological(More)
Abstract Unconstrained point-to-point reaching movements performed in the horizontal plane tend to follow roughly straight hand paths with smooth, bell-shaped velocity profiles. The objective of the research reported here was to explore the hypothesis that these data reflect an underlying learning process that prefers simple paths in space. Under this(More)
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