Yadwinder Singh

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Different groups of pregnant rats were treated with diazepam (10 mg/kg), phenobarbital (10 mg/kg), haloperidol (0.1 mg/kg), fluoxetine (10 mg/kg) and vehicle (normal saline) intraperitoneally once a day during gestation days 13 to 21. After birth these pups were culled to 8 pups/dam and foster-nursed by lactating mothers for 3 weeks and were reared in(More)
OBJECTIVE The efficacy of buspirone in controlling self-injurious behavior was examined in five individuals with mental retardation. Buspirone was used alone in two individuals and as an adjunct to thioridazine in the other three. METHOD Standard behavioral observation methods were used to collect data on the number of self-injurious responses of the(More)
Certain antibiotics can induce neuromuscular paralysis, but the mechanism of this action is largely unknown. The purpose of this study was to compare the neuromuscular blocking potencies and reversibilities of 16 antibiotics in the isolated mouse phrenic nerve-hemidiaphragm preparation. The antibiotics tested were five aminoglycosides (neomycin, gentamicin,(More)
SUMMARY In an attempt to elucidate the mechanisms by which antibiotics induce muscle paralysis, the effects of streptomycin, lincomycin, polymyxin B and clindamycin were investigated in the mouse phrenic nerve-hemidiaphragm preparation. Streptomycin resembled magnesium in reducing miniature endplate potential (m.e.p.p.) amplitude and frequency, whereas(More)
Haloperidol (0.1 mg/kg, i.p.) treatment was given from day 12 to 20 of gestation to pregnant rats, this being the critical period for neural development in this species. The pups born were subjected to open-field exploratory behaviour, tunnel-board exploratory behaviour, elevated zero-maze and elevated plus maze behaviour tests at 7-8 weeks of age. The(More)
The effects of seven antibiotics (streptomycin, amikacin, polymyxin B, lincomycin, clindamycin, tetracycline and oxytetracycline) were compared with those of magnesium, tubocurarine and lignocaine in the frog sciatic nerve--sartorius muscle preparation, using intracellular recording techniques. All compounds except tubocurarine decreased end-plate potential(More)
Dysfunction of the serotonergic system has been implicated in the development and maintenance of self-injury in some persons with mental retardation. Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individuals. Of the 44 cases of self-injury treated with fluoxetine(More)
The effects of the new aminoglycoside antibiotic amikacin on neurohumoral transmission were tested in the anaesthetized cat, and in mouse, rat and chick isolated nerve-muscle preparations. Amikacin had blocking actions on both autonomic and neuromuscular transmission. The autonomic effects were caused mainly by ganglion blockade and were reversed by(More)
An electrophysiological study was made of the effects of four adenosine analogues, 2-chloroadenosine (2-CIA), 5'-N-ethylcarboxamidoadenosine (NECA), L-N6-phenylisopropyladenosine (L-PIA), and 2-(p-methoxyphenyl)-adenosine (CV-1674) on neurotransmitter release in the mouse phrenic nerve - hemidiaphragm preparation. All four drugs decreased miniature(More)