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'miR2Disease', a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. The current version of miR2Disease documents 1939 curated relationships between 299 human microRNAs and 94 human diseases by reviewing more than 600 published papers. Around one-seventh of the microRNA-disease(More)
MOTIVATION The development of high-throughput sequencing technologies has enabled novel methods for detecting structural variants (SVs). Current methods are typically based on depth of coverage or pair-end mapping clusters. However, most of these only report an approximate location for each SV, rather than exact breakpoints. RESULTS We have developed(More)
Complex numbers appear naturally in biology whenever a system can be analyzed in the frequency domain, such as physiological data from magnetoencephalography (MEG). For example, the MEG steady state response to a modulated auditory stimulus generates a complex magnetic field for each MEG channel, equal to the Fourier transform at the stimulus modulation(More)
Feature-weight assignment can be regarded as a generalization of feature selection. That is, if all values of feature-weights are either 1 or 0, feature-weight assignment degenerates to the special case of feature selection. Generally speaking, a number in ½0; 1Š can be assigned to a feature for indicating the importance of the feature. This paper shows(More)
Genetic variations in metabolic genes are thought to modify the metabolic process of carcinogens and are suggested to be related to cancer risk. However, epidemiological results are not always consistent. In this meta-analysis, we assessed reported studies of associations between polymorphisms of CYP2E1 RsaI/PstI and DraI, and the risk of lung cancer. We(More)
T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to immune activation and disease aggravation in patients with HBV infection is not fully clear. In this study, we investigated the Th17 cells frequencies and interleukin-17 (IL-17) mRNA(More)
BACKGROUND AND AIM Differentiating Crohn's disease from intestinal tuberculosis often challenges clinicians in countries where tuberculosis and Crohn's disease coexist. The aim of this study was to screen out clinical, endoscopic and histological features which may be helpful in distinguishing Crohn's disease from intestinal tuberculosis. METHODS 43(More)
Current applications of microarrays focus on precise classification or discovery of biological types, for example tumor versus normal phenotypes in cancer research. Several challenging scientific tasks in the post-genomic epoch, like hunting for the genes underlying complex diseases from genome-wide gene expression profiles and thereby building the(More)
DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry. This is associated with induction of dsRNAs(More)
Coke oven workers are regularly exposed to polycyclic aromatic hydrocarbons (PAHs) and have a high risk for lung cancer. Limited evidence has demonstrated a direct link between exposure to PAHs and early genetic damage in exposed workers. The cytokinesis-block micronucleus (CBMN) cytome assay is a comprehensive system for measuring DNA damage and(More)