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Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract
TLDR
GbE inhibited production of pro- inflammatory cytokines IL-1β and TNF-α, but upregulated the production of anti-inflammatory cytokines, IL-10 andIL-10R in brain, which might be related with its anti-AS actions. Expand
Bcl-XL and Mcl-1 upregulation by calreticulin promotes apoptosis resistance of fibroblast-like synoviocytes via activation of PI3K/Akt and STAT3 pathways in rheumatoid arthritis.
TLDR
This study showed that upregulation of Bcl-XL and Mcl-1 expression in RA FLS by CRT were PI3K/Akt and STAT3 signal pathways dependent, and promoted the anti-apoptosis ofRA FLS, which may represent a therapeutic target for the treatment of RA. Expand
Effects of Ginkgo biloba extract on expressions of IL-1beta, TNF-alpha, and IL-10 in U937 foam cells.
TLDR
GbE inhibited production of pro- inflammatory cytokines IL-1beta and TNF-alpha, but up-regulated the production of anti-inflammatory cytokine IL-10 and its receptor IL- 10R in U937 foam cells, which might be related with its anti-atherosclerotic actions. Expand
The inhibitional effect of calreticulin on tumour necrosis factor-related apoptosis-inducing ligand-mediated T cell apoptosis in rheumatoid arthritis
Objective To investigate the anti-apotoptic effects of calreticulin (CRT) on tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated T cells apoptosis in rheumatoid arthritis (RA).Expand
Serum amyloid A induces the formation of neutrophil extracellular traps via Toll like receptor 4 in rheu-matoid arthritis
Objective To investigate the neutrophil extracellular traps (NETs) formation and their molecular mechanisms induced by serum amyloid A (SAA) in rheumatoid arthritis (RA). Methods NeutrophilsExpand