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OBJECTIVE Proliferation of vascular smooth muscle cells (VSMCs) contributes to restenosis after coronary intervention. We have shown previously that increased expression of plasminogen activator inhibitor type 1 (PAI-1) limits VSMC apoptosis. Because apoptosis and proliferation appear to be linked, we sought to determine whether increased PAI-1 would affect(More)
We have shown that both free fatty acids (FFA) and triglycerides (TG) increase expression of plasminogen activator inhibitor type 1 (PAI-1) in vivo and in vitro. To determine signaling mechanisms responsible, HepG2 cells were exposed to FFA, emulsified TG, or the combination. The combination of FFA and TG increased PAI-1 to a greater extent than either(More)
Big data analytic technologies such as Hadoop and Spark run on compute clusters that are managed by resource managers such as YARN. YARN manages resources available to individual applications, thereby affecting job performance. Manual tuning of YARN tuning parameters can result in sub-optimal and brittle performance. Parameters that are optimal for one job(More)
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