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The existing algorithms for the minimum concave cost network flow problems mainly focus on the single-source problems. To handle both the single-source and the multiple-source problem in the same way, especially the problems with dense arcs, a deterministic annealing algorithm is proposed in this paper. The algorithm is derived from an application of the(More)
The aim of this study was to test the ability of paclitaxel-loaded poly(butylcyanoacrylate) (PBCA) nanoparticles to overcome multidrug resistance (MDR) in human ovarian resistant cells (A2780/T) and investigate its possible mechanism. We prepared paclitaxel-loaded PBCA nanoparticles by interfacial polymerization method. The physicochemistry of the(More)
The water dispersion of poly-N-isopropylacrylamide hybrid nanoparticles exhibited temperature-triggered magnetic separation behaviour: if the temperature switched between below and above 32 degrees C, the nanoparticles could be dispersed into water and reversibly separated by a magnetic field of 1.1 T.
Ginger (Zingiber officinale) has been traditionally used to check hair loss and stimulate hair growth in East Asia. Several companies produce shampoo containing an extract of ginger claimed to have anti-hair loss and hair growth promotion properties. However, there is no scientific evidence to back up these claims. This study was undertaken to measure(More)
OBJECTIVE The aim of the study was to observe the characteristic of permeation of capsaicin across jejunum, ileum and colon in the rat, and to investigate the role of transient receptor potential cation channel (TRPV1). The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance(More)
The transition from acute pain to chronic pain entails considerable changes of patients at multiple levels of the nervous system and in psychological states. An accurate differentiation between acute and chronic pain is essential in pain management as it may help optimize analgesic treatments according to the pain state of patients. Given that acute and(More)
In this paper, a semi-analytical model for the gate-to-source/drain fringing capacitance (Cf) of MOSFET including process variations is presented. Cf is defined as a layout-dependent parasitic capacitance separated from gate-to-contact capacitance (Cco), and is composed of several dual-k perpendicular-plate capacitances. Layout-dependent coefficients such(More)
An accurate and efficient base resistance (R<sub>B</sub>) extraction methodology for SiGe HBT HICUM model is developed in this paper. Differing from previous methods, the proposed technique is based on the rational function fitting. Two formulas are used to determine the lower and upper limits of R<sub>B</sub>, and then R<sub>B</sub> is confined to a very(More)
The classic Kalman filter implementation uses the measurements up to the time of forecast to update the initial conditions of the numerical model, with the updating effect limited to a prediction horizon when the improved initial conditions are washed out. To further enhance the prediction capability, this study proposes a new hybrid data assimilation(More)